Discovery of Potent and Selective Reversible Ubiquitin-Like Modifier Activating Enzyme 5 Inhibitors Targeting the UFMylation Pathway.
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DOI: 10.1021/acs.jmedchem.5c02305
Abstract: Ubiquitin-like modifier activating enzyme 5 (UBA5), an E1 enzyme in the UFMylation pathway, is of interest as a therapeutic target in diseases such as cancer due to the critical role that UFMylation plays in cellular… read more here.
Keywords: modifier activating; potent selective; ufmylation pathway; ubiquitin like ... See more keywords