A Critical Role of δ-Opioid Receptor in Anti-microglial Activation Under Stress
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DOI: 10.3389/fnagi.2022.847386
Abstract: Microglia are involved in the regulation of cerebral homeostasis and pathogen confrontation. There is, however, evidence showing that excessive microglia activation is implicated in various age-related cerebral diseases. On the other hand, microglia may experience… read more here.
Keywords: dor; opioid receptor; microglial activation; ufp 512 ... See more keywords
Treatment With the Delta Opioid Agonist UFP-512 Alleviates Chronic Inflammatory and Neuropathic Pain: Mechanisms Implicated
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DOI: 10.3389/fphar.2019.00283
Abstract: We investigated whether administration of the δ-opioid receptor (DOR) agonist H-Dmt-Tic-NH-CH(CH2-COOH)-Bid (UFP-512), which also activates nuclear factor erythroid 2-related factor 2 (Nrf2), alleviated chronic inflammatory and/or neuropathic pain and inhibited the depressive-like behaviors associated with… read more here.
Keywords: ufp 512; agonist; pain; chronic inflammatory ... See more keywords