Oxidative Deaminations and Deisatinylations of Ugi-Azide and Ugi-3CR Products: A Two-Step MCR-Oxidation Protocol toward Functionalized α-Ketoamides and α-Ketotetrazoles.
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DOI: 10.1021/acs.orglett.7b00710
Abstract: A new postcondensation multicomponent reaction (MCR) methodology, comprising oxidative deaminations enabling access to multiple privileged carbonyl-containing scaffolds in two steps, is described. These protocols allow facile access to functionalized α-ketoamide and α-ketotetrazole small-molecule peptidomimetic-like building… read more here.
Keywords: deaminations deisatinylations; azide ugi; oxidative deaminations; ugi azide ... See more keywords
Consecutive hydrazino-Ugi-azide reactions: synthesis of acylhydrazines bearing 1,5-disubstituted tetrazoles
Sign Up to like & getrecommendations! Published in 2017 at "Beilstein Journal of Organic Chemistry"
DOI: 10.3762/bjoc.13.256
Abstract: Isocyanide-based multicomponent reactions (IMCRs) allow the construction of relatively complex molecules through a one-pot synthesis. The combination of IMCRs in a consecutive or sequential fashion further extends the complexity of the molecules obtained. Herein, we… read more here.
Keywords: disubstituted tetrazoles; ugi azide; acylhydrazines bearing; hydrazino ugi ... See more keywords