Cyclic Imines in Ugi and Ugi-Type Reactions.
Sign Up to like & getrecommendations! Published in 2020 at "ACS combinatorial science"
DOI: 10.1021/acscombsci.0c00046
Abstract: Ugi four-component reactions (U-4CRs) are widely recognized as being highly efficient for the synthesis of pseudopeptides. However, the products of these reactions are not so interesting as drug candidates because they are not conformationally restricted… read more here.
Keywords: imines ugi; component; cyclic imines; ugi type ... See more keywords
Cu(OTf)2 catalyzed Ugi-type reaction of N,O-acetals with isocyanides for the synthesis of pyrrolidinyl and piperidinyl 2-carboxamides.
Sign Up to like & getrecommendations! Published in 2021 at "Chemical communications"
DOI: 10.1039/d1cc03113a
Abstract: The Cu(OTf)2 catalyzed Ugi-type reactions of N,O-acetals with isocyanides have been described for the synthesis of pyrrolidinyl and piperidinyl 2-carboxamides. 4-Hydroxy-5-substituted-prolinamides can be obtained in high diastereoselectivities (2,4-cis/trans > 19 : 1) and a stereoselective model was… read more here.
Keywords: otf catalyzed; catalyzed ugi; ugi type; pyrrolidinyl piperidinyl ... See more keywords