Computational Prediction of Site of Metabolism for UGT-Catalyzed Reactions
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DOI: 10.1021/acs.jcim.8b00851
Abstract: The investigation of metabolically liable sites of xenobiotics mediated by UDP-glucuronosyltransferases (UGTs) is important for lead optimization in early drug discovery. However, it is time-consuming and costly to identify potentially susceptible sites experimentally. Hence, in… read more here.
Keywords: metabolism; computational prediction; ugt catalyzed; site metabolism ... See more keywords