In vitro inhibition of human UGT isoforms by ritonavir and cobicistat
Sign Up to like & getrecommendations! Published in 2018 at "Xenobiotica"
DOI: 10.1080/00498254.2017.1370655
Abstract: Abstract 1. Ritonavir and cobicistat are pharmacokinetic boosting agents used to increase systemic exposure to other antiretroviral therapies. The manufacturer’s data suggests that cobicistat is a more selective CYP3A4 inhibitor than ritonavir. However, the inhibitory effect… read more here.
Keywords: ritonavir cobicistat; human ugt; ugt isoforms; inhibition human ... See more keywords
Ginsenoside Rc Is a New Selective UGT1A9 Inhibitor in Human Liver Microsomes and Recombinant Human UGT Isoforms
Sign Up to like & getrecommendations! Published in 2019 at "Drug Metabolism and Disposition"
DOI: 10.1124/dmd.119.087965
Abstract: Ginseng is known to have inhibitory effects on UGT1A9 activity. However, little is known about the inhibitory effects of ginsenosides, the major active compounds in ginseng, on UGT1A9 activity. In vitro investigation of UGT1A9 inhibition… read more here.
Keywords: inhibitor; ugt isoforms; liver microsomes; human liver ... See more keywords