Impact of UGT1A1 polymorphisms on Raltegravir and its glucuronide plasma concentrations in a cohort of HIV-1 infected patients
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-25803-z
Abstract: The aim of this study was to evaluate the effect of UGT1A1 polymorphisms on Raltegravir (RAL) and its metabolite RAL-glucuronide trough plasma concentrations ([RAL]plasma and [RAL-glu]plasma) and on the metabolic ratio (MR): [RAL-glu]plasma/[RAL]plasma. UGT1A1 genotyping… read more here.
Keywords: polymorphisms raltegravir; plasma concentrations; ugt1a1 polymorphisms; ugt1a1 ugt1a1 ... See more keywords
UGT1A1 polymorphisms in rectal cancer associated with the efficacy and toxicity of preoperative chemoradiotherapy using irinotecan
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DOI: 10.1111/cas.13807
Abstract: The purpose of the present study was to assess the efficacy and toxicity of preoperative chemoradiotherapy using irinotecan against locally advanced lower rectal cancer according to UDPâglucuronosyltransferase 1A1 (UGT1A1) polymorphisms. Between 2009 and 2016, 46… read more here.
Keywords: rectal cancer; preoperative chemoradiotherapy; chemoradiotherapy; ugt1a1 polymorphisms ... See more keywords
UGT1A1 polymorphism has a prognostic effect in patients with stage IB or II uterine cervical cancer and one or no metastatic pelvic nodes receiving irinotecan chemotherapy: a retrospective study
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DOI: 10.1186/s12885-020-07225-1
Abstract: Background Uridine diphosphate glucuronosyltransferase 1 family polypeptide A1 ( UGT1A1 ) is a predictive biomarker for the side-effects of irinotecan chemotherapy, which reduces the volume of tumors harboring UGT1A1 polymorphisms. We aimed to determine whether… read more here.
Keywords: chemotherapy; irinotecan chemotherapy; ugt1a1 polymorphisms; cervical cancer ... See more keywords
Profiling of UGT1A1*6, UGT1A1*60, UGT1A1*93, and UGT1A1*28 Polymorphisms in Indonesian Neonates With Hyperbilirubinemia Using Multiplex PCR Sequencing
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Pediatrics"
DOI: 10.3389/fped.2019.00328
Abstract: Background: Single nucleotide polymorphism (SNP) variants of the uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) gene have been studied as an important factor in neonatal hyperbilirubinemia (jaundice) severity. Specific ethnicities, including Asians, have certain SNPs that appear… read more here.
Keywords: ugt1a1 polymorphisms; ugt1a1 ugt1a1; hyperbilirubinemia; pcr ... See more keywords
Impact of UGT1A1 Polymorphisms on Febrile Neutropenia in Pancreatic Cancer Patients Receiving FOLFIRINOX: A Single-Center Cohort Study
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DOI: 10.3390/cancers14051244
Abstract: Simple Summary FOLFIRINOX, which is a first-line chemotherapy for metastatic pancreatic cancer, has become one of the high-risk regimens related to developing febrile neutropenia (FN). Although UGT1A1 polymorphisms are associated with the metabolism of irinotecan,… read more here.
Keywords: metabolizer; pancreatic cancer; ugt1a1 polymorphisms; group ... See more keywords