SET8 prevents excessive DNA methylation by methylation-mediated degradation of UHRF1 and DNMT1
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DOI: 10.1093/nar/gkz626
Abstract: Abstract Faithful inheritance of DNA methylation across cell division requires DNMT1 and its accessory factor UHRF1. However, how this axis is regulated to ensure DNA methylation homeostasis remains poorly understood. Here we show that SET8,… read more here.
Keywords: methylation; dna methylation; uhrf1 dnmt1; set8 ... See more keywords
Coordinated Dialogue between UHRF1 and DNMT1 to Ensure Faithful Inheritance of Methylated DNA Patterns
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DOI: 10.3390/genes10010065
Abstract: DNA methylation, catalyzed by DNA methyltransferases (DNMTs), is an epigenetic mark that needs to be faithfully replicated during mitosis in order to maintain cell phenotype during successive cell divisions. This epigenetic mark is located on… read more here.
Keywords: methylation; dna; uhrf1 dnmt1; inheritance ... See more keywords