Performance of a Deep Learning Model vs Human Reviewers in Grading Endoscopic Disease Severity of Patients With Ulcerative Colitis
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DOI: 10.1001/jamanetworkopen.2019.3963
Abstract: Key Points Question What is the agreement of automatically determined endoscopic severity of ulcerative colitis using deep learning models compared with expert human reviewers? Findings In this diagnostic study including colonoscopy data from 3082 adults,… read more here.
Keywords: severity; ulcerative colitis; human reviewers; deep learning ... See more keywords
Integrative computational approach identifies immune‐relevant biomarkers in ulcerative colitis
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DOI: 10.1002/2211-5463.13357
Abstract: Ulcerative colitis is a common inflammatory bowel disease with a complex genetic and immune etiology. Immune infiltration plays a vital role in the development of ulcerative colitis. To explore potential biomarkers for ulcerative colitis and… read more here.
Keywords: olfm4 dpp10; cep55 acsl1; biomarkers ulcerative; colitis ... See more keywords
Oligoethyleneimine‐Conjugated Hyaluronic Acid Modulates Inflammatory Responses and Enhances Therapeutic Efficacy for Ulcerative Colitis
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DOI: 10.1002/adfm.202100548
Abstract: Modulation of innate immune responses is a potential strategy for treating inflammatory diseases. Although biogenic polyamines are known as immunomodulatory compounds possessing anti‐inflammatory functions, their biomedical applications have been limited owing to their cytotoxicity. Here,… read more here.
Keywords: therapeutic efficacy; hyaluronic acid; inflammatory responses; ulcerative colitis ... See more keywords
Hydrogel Derived from Decellularized Porcine Small Intestinal Submucosa as a Physical Shielding Repaired the Gut Epithelial Barrier of Murine Ulcerative Colitis
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DOI: 10.1002/adfm.202405601
Abstract: Ulcerative colitis (UC) is associated with the shedding of the gut mucus. Decellularized porcine small intestinal submucosa (SIS‐ECM) contains numerous active forms of extracellular matrix as well as growth factors. Herein, a mucus‐mimetic hydrogel (MAG)… read more here.
Keywords: intestinal submucosa; decellularized porcine; ulcerative colitis; porcine small ... See more keywords
Oral Targeted MXenzyme – Armed Probiotic Regulates Intestinal Redox and Microbiota Homeostasis to Synergistically Ameliorate Ulcerative Colitis
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DOI: 10.1002/adfm.202421680
Abstract: Ulcerative colitis (UC) leads to complex alterations in the intestinal microenvironment, with gut microbiota dysbiosis and excessive reactive oxygen species (ROS) being major drivers. Previously, microecological preparations have been used to restore intestinal homeostasis and… read more here.
Keywords: akk v2c; homeostasis; ulcerative colitis; microbiota homeostasis ... See more keywords
Melittin‐Loaded Multifunctional Nanozyme for Ulcerative Colitis Treatment via Enzyme‐Immunotherapy and Ferroptosis Inhibition
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DOI: 10.1002/adfm.202503374
Abstract: In ulcerative colitis (UC), oxidative stress (OS) and iron overload disrupt immune homeostasis and intestinal barrier function, exacerbating inflammation through effects on macrophages and intestinal epithelial cells (IECs). Reversing macrophage‐driven inflammation and restoring homeostasis of… read more here.
Keywords: pda mel; mel; homeostasis; ulcerative colitis ... See more keywords
Colon‐Targeted Ginseng Polysaccharides‐Based Microspheres for Improving Ulcerative Colitis via Anti‐Inflammation and Gut Microbiota Modulation
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DOI: 10.1002/adhm.202404122
Abstract: Natural plant‐derived polysaccharides exhibit substantial potential for treating ulcerative colitis (UC) owing to their anti‐inflammatory and antioxidant properties and favorable safety profiles. However, their practical application faces several challenges, including structural instability in gastric acid,… read more here.
Keywords: ginseng polysaccharides; gut microbiota; colon; ulcerative colitis ... See more keywords
A Biomimetic Sweeping Microrobot for Active Therapy of Ulcerative Colitis
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DOI: 10.1002/adma.202402579
Abstract: Overproduction of pathogenic cell‐free DNA (cfDNA) and reactive oxygen species (ROS) plays crucial roles in the onset and perpetuation of ulcerative colitis (UC). Inspired by sweeping robots, a magnesium@polylactic acid‐glycolic acid copolymer@polyethylenimine (Mg@PLGA@PEI) microswimmer capable… read more here.
Keywords: active therapy; plga pei; cfdna; ulcerative colitis ... See more keywords
Prodrug Integrated Envelope on Probiotics to Enhance Target Therapy for Ulcerative Colitis
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DOI: 10.1002/advs.202205422
Abstract: Ulcerative colitis (UC), affecting millions of patients worldwide, is associated with disorders of the gut microbiota. Probiotics‐based therapy positively regulating the community structure of gut microbiota is regarded as an efficient intervention for UC. However,… read more here.
Keywords: gut microbiota; therapy; colitis; ulcerative colitis ... See more keywords
A Curcumin-Modified Coordination Polymers with ROS Scavenging and Macrophage Phenotype Regulating Properties for Efficient Ulcerative Colitis Treatment.
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DOI: 10.1002/advs.202300601
Abstract: Overexpression of classically activated macrophages (M1) subtypes and assessed reactive oxygen species (ROS) levels are often observed in patients with ulcerative colitis. At present, the treatment system of these two problems has yet to be… read more here.
Keywords: ulcerative colitis; colitis; curcumin modified; modified coordination ... See more keywords
Bioinspired Claw‐Engaged Adhesive Microparticles Armed with γGC Alleviate Ulcerative Colitis via Targeted Suppression of Macrophage Ferroptosis
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DOI: 10.1002/advs.202503903
Abstract: Ulcerative colitis (UC) is a chronic inflammatory bowel disease, characterized by focal iron overload. Herein, we reported that γ‐glutamylcysteine (γGC) deletion in UC lesions intensified the disease by depleting intracellular GSH to induce macrophage ferroptosis,… read more here.
Keywords: macrophage ferroptosis; macrophage; ulcerative colitis; bioinspired claw ... See more keywords