Performance of a Deep Learning Model vs Human Reviewers in Grading Endoscopic Disease Severity of Patients With Ulcerative Colitis
Sign Up to like & getrecommendations! Published in 2019 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2019.3963
Abstract: Key Points Question What is the agreement of automatically determined endoscopic severity of ulcerative colitis using deep learning models compared with expert human reviewers? Findings In this diagnostic study including colonoscopy data from 3082 adults,… read more here.
Keywords: severity; ulcerative colitis; human reviewers; deep learning ... See more keywords
Integrative computational approach identifies immune‐relevant biomarkers in ulcerative colitis
Sign Up to like & getrecommendations! Published in 2021 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13357
Abstract: Ulcerative colitis is a common inflammatory bowel disease with a complex genetic and immune etiology. Immune infiltration plays a vital role in the development of ulcerative colitis. To explore potential biomarkers for ulcerative colitis and… read more here.
Keywords: olfm4 dpp10; cep55 acsl1; biomarkers ulcerative; colitis ... See more keywords
Oligoethyleneimine‐Conjugated Hyaluronic Acid Modulates Inflammatory Responses and Enhances Therapeutic Efficacy for Ulcerative Colitis
Sign Up to like & getrecommendations! Published in 2021 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202100548
Abstract: Modulation of innate immune responses is a potential strategy for treating inflammatory diseases. Although biogenic polyamines are known as immunomodulatory compounds possessing anti‐inflammatory functions, their biomedical applications have been limited owing to their cytotoxicity. Here,… read more here.
Keywords: therapeutic efficacy; hyaluronic acid; inflammatory responses; ulcerative colitis ... See more keywords
Prodrug Integrated Envelope on Probiotics to Enhance Target Therapy for Ulcerative Colitis
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202205422
Abstract: Ulcerative colitis (UC), affecting millions of patients worldwide, is associated with disorders of the gut microbiota. Probiotics‐based therapy positively regulating the community structure of gut microbiota is regarded as an efficient intervention for UC. However,… read more here.
Keywords: gut microbiota; therapy; colitis; ulcerative colitis ... See more keywords
A Curcumin-Modified Coordination Polymers with ROS Scavenging and Macrophage Phenotype Regulating Properties for Efficient Ulcerative Colitis Treatment.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202300601
Abstract: Overexpression of classically activated macrophages (M1) subtypes and assessed reactive oxygen species (ROS) levels are often observed in patients with ulcerative colitis. At present, the treatment system of these two problems has yet to be… read more here.
Keywords: ulcerative colitis; colitis; curcumin modified; modified coordination ... See more keywords
Ferulic acid relieved ulcerative colitis by inhibiting the TXNIP/NLRP3 pathway in rats
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11935
Abstract: Ulcerative colitis (UC) is a disorder of the bowel that is characterized by a chronic inflammatory response. The traditional Chinese herbal medicine ferulic acid (FA) is known for its antioxidant, antiapoptotic, and antiinflammatory properties. However,… read more here.
Keywords: nlrp3 signaling; ulcerative colitis; pathway; txnip nlrp3 ... See more keywords
A Phase 1 Study of KHK4083: A Single‐Blind, Randomized, Placebo‐Controlled Single‐Ascending‐Dose Study in Healthy Adults and an Open‐Label Multiple‐Dose Study in Patients With Ulcerative Colitis
Sign Up to like & getrecommendations! Published in 2021 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.918
Abstract: OX40 plays an essential role in maintaining late T‐cell proliferation and survival by suppressing apoptosis and by inducing T‐cell memory formation. Here, we report the results of the phase 1 study of KHK4083, a fully… read more here.
Keywords: study khk4083; study; ulcerative colitis; dose ... See more keywords
Somatic mutation profiles as molecular classifiers of ulcerative colitis‐associated colorectal cancer
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Cancer"
DOI: 10.1002/ijc.33492
Abstract: Ulcerative colitis increases colorectal cancer risk by mechanisms that remain incompletely understood. We approached this question by determining the genetic and epigenetic profiles of colitis‐associated colorectal carcinomas (CA‐CRC). The findings were compared to Lynch syndrome… read more here.
Keywords: colorectal cancer; group; ulcerative colitis; colitis associated ... See more keywords
Infrared spectrometric biomarkers for ulcerative colitis screening using human serum samples
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biophotonics"
DOI: 10.1002/jbio.202100307
Abstract: This study uses infrared spectrometry coupled with data analysis techniques to understand colitis‐induced alterations in the molecular components of serum samples. Using samples from 18 ulcerative colitis patients and 28 healthy volunteers, we assessed features… read more here.
Keywords: biomarkers ulcerative; spectrometric biomarkers; serum samples; colitis ... See more keywords
Adsorptive granulocyte/monocyte apheresis use in severe ulcerative colitis and determination of changes in plasma cytokines
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Apheresis"
DOI: 10.1002/jca.21552
Abstract: Despite controversy regarding the use of granulocyte/monocyte adsorption (GMA) in inflammatory bowel disease, some studies have shown favorable outcomes when it is used in steroid‐dependent patients with ulcerative colitis (UC). The mechanisms responsible for such… read more here.
Keywords: granulocyte monocyte; use; changes plasma; gma ... See more keywords
Concomitant pharmacologic medications influence the clinical outcomes of granulocyte and monocyte adsorptive apheresis in patients with ulcerative colitis: A multicenter retrospective cohort study.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of clinical apheresis"
DOI: 10.1002/jca.22040
Abstract: BACKGROUND Granulocyte and monocyte adsorptive apheresis (GMA) with Adacolumn has been used as a remission induction therapy for patients with active ulcerative colitis (UC). Herein, we investigated the influence of concomitant medications in the remission… read more here.
Keywords: granulocyte monocyte; multicenter retrospective; apheresis; monocyte adsorptive ... See more keywords