Ulipristal acetate for Japanese women with symptomatic uterine fibroids: A double‐blind, randomized, phase II dose‐finding study
Sign Up to like & getrecommendations! Published in 2020 at "Reproductive Medicine and Biology"
DOI: 10.1002/rmb2.12304
Abstract: A multicenter, randomized, double‐blind, placebo‐controlled trial was conducted to evaluate the efficacy, safety, and appropriate dose of ulipristal acetate (UPA) in Japanese women with symptomatic uterine fibroids (UFs). read more here.
Keywords: uterine fibroids; ulipristal acetate; japanese women; women symptomatic ... See more keywords
The progesterone-receptor modulator, ulipristal acetate, drastically lowers breast cell proliferation
Sign Up to like & getrecommendations! Published in 2022 at "Breast Cancer Research and Treatment"
DOI: 10.1007/s10549-021-06503-1
Abstract: The proliferation of breast epithelial cells increases during the luteal phase of the menstrual cycle, when they are exposed to progesterone, suggesting that ulipristal acetate, a selective progestin-receptor modulator (SPRM), may reduce breast cell proliferation… read more here.
Keywords: breast; breast cell; proliferation; treatment ... See more keywords
Combined oral contraceptive interference with the ability of ulipristal acetate to delay ovulation: A prospective cohort study.
Sign Up to like & getrecommendations! Published in 2018 at "Contraception"
DOI: 10.1016/j.contraception.2018.08.003
Abstract: OBJECTIVE To determine if a combined oral contraceptive (COC) initiated shortly after ulipristal acetate (UPA) administration interferes with its mechanism of action. STUDY DESIGN Healthy, reproductive-age women of normal BMI with proven ovulation (serum progesterone… read more here.
Keywords: combined oral; study; cycle; ulipristal acetate ... See more keywords
Ulipristal acetate compared to levonorgestrel emergency contraception among current oral contraceptive users: a cost-effectiveness analysis.
Sign Up to like & getrecommendations! Published in 2019 at "Contraception"
DOI: 10.1016/j.contraception.2019.05.004
Abstract: OBJECTIVE To estimate the cost-effectiveness of ulipristal acetate (UPA) and levonorgestrel (LNG) emergency contraception (EC) on pregnancy prevention among combined oral contraceptive (COC) pill users with an extended pill-free interval. We accounted for the potential… read more here.
Keywords: emergency contraception; ulipristal acetate; oral contraceptive; cost effectiveness ... See more keywords
Pharmacodynamics and pharmacokinetics of a copper intrauterine contraceptive system releasing ulipristal acetate: a randomized proof-of-concept study.
Sign Up to like & getrecommendations! Published in 2021 at "Contraception"
DOI: 10.1016/j.contraception.2021.06.010
Abstract: OBJECTIVES To assess pharmacodynamic and pharmacokinetic outcomes of a novel copper (Cu) intrauterine system (IUS) releasing ulipristal acetate (UPA) in healthy women. STUDY DESIGN In this single-blinded, randomized proof-of-concept study, ovulatory women received one of… read more here.
Keywords: copper intrauterine; releasing ulipristal; randomized proof; study ... See more keywords
Ulipristal acetate decreases active TGF-β3 and its canonical signaling in uterine leiomyoma via two novel mechanisms.
Sign Up to like & getrecommendations! Published in 2019 at "Fertility and sterility"
DOI: 10.1016/j.fertnstert.2018.12.026
Abstract: OBJECTIVE To characterize the effect of ulipristal acetate (UPA) treatment on transforming growth factor (TGF) canonical and noncanonical signaling pathways in uterine leiomyoma tissue and cells. UPA decreased extracellular matrix in surgical specimens; we characterize… read more here.
Keywords: active tgf; canonical signaling; tgf canonical; ulipristal acetate ... See more keywords
Unexpected Uterine Leiomyosarcoma During Laparoscopic Hysterectomy Treated 6 Months With Ulipristal Acetate and Contained Power Morcellation.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of minimally invasive gynecology"
DOI: 10.1016/j.jmig.2016.08.004
Abstract: DESIGN A 45-year-old woman with a symptomatic uterine myoma suffering from heavy menstrual bleeding, incontinence, and pain pressure received ulipristal acetate (UPA [Esmya; Gideon Richter, Budapest, Hungary]) for 6 months. SETTING A Minimal Invasive Gynecology… read more here.
Keywords: ulipristal acetate; uterine leiomyosarcoma; unexpected uterine; laparoscopic hysterectomy ... See more keywords
A Multicenter Study Evaluating the Effect of Ulipristal Acetate during Myomectomy.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of minimally invasive gynecology"
DOI: 10.1016/j.jmig.2017.10.016
Abstract: STUDY OBJECTIVE To compare surgical experience at myomectomy between patients with myomas pretreated with ulipristal acetate versus no pretreatment. DESIGN A prospective, observational, multicenter study of myomectomy procedures by any route (hysteroscopic, laparoscopic, or laparotomy)… read more here.
Keywords: acetate; study; laparotomic laparoscopic; ulipristal acetate ... See more keywords
Ulipristal Acetate Improves Clinical Symptoms in Women with Adenomyosis and Uterine Myomas.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of minimally invasive gynecology"
DOI: 10.1016/j.jmig.2018.04.002
Abstract: STUDY OBJECTIVE To study the effects of ulipristal acetate (UPA) on adenomyosis-associated clinical symptoms. DESIGN A retrospective, single-center observational study (Canadian Task Force classification II-2). SETTING A university tertiary referral center. PATIENTS Premenopausal women (163)… read more here.
Keywords: group; study; clinical symptoms; ulipristal acetate ... See more keywords
What does non-eligibility for myoma surgery mean in the context of sequential prescription of ulipristal acetate?
Sign Up to like & getrecommendations! Published in 2020 at "Journal of gynecology obstetrics and human reproduction"
DOI: 10.1016/j.jogoh.2020.101688
Abstract: Ulipristal Acetate (UPA) is the only selective progesterone receptor modulator currently approved for medical management of myomas. Following several cases of liver toxicity during UPA treatment, new recommendations of PRAC (Pharmacovigilance Risk Assessment Committee) and… read more here.
Keywords: surgery; ulipristal acetate; non eligibility; eligibility myoma ... See more keywords
Ulipristal acetate for the management of large uterine fibroids associated with heavy bleeding: a review.
Sign Up to like & getrecommendations! Published in 2018 at "Reproductive biomedicine online"
DOI: 10.1016/j.rbmo.2018.04.040
Abstract: Ulipristal acetate (UPA), a selective progesterone receptor modulator (SPRM), offers new therapeutic options for the clinical management of large uterine fibroids associated with heavy menstrual bleeding or with other moderate or severe symptoms (bulk symptoms,… read more here.
Keywords: large uterine; fibroids associated; management large; ulipristal acetate ... See more keywords