Asymmetric Umpolung (3+2) Cycloadditions of Iminoesters with α,β-Unsaturated-2-acyl Imidazoles for the Synthesis of Substituted Pyrrolidines.
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DOI: 10.1021/acs.orglett.2c01438
Abstract: An enantioselective (3+2) cycloaddition reaction of iminoesters occurring with opposite regioselectivity is reported. This reaction provides chiral polysubstituted pyrrolidines with high enantioselectivities (up to 97%), diastereoselectivities (>20:1), and yields (up to 99%). Interestingly, changing the… read more here.
Keywords: iminoesters unsaturated; asymmetric umpolung; cycloadditions iminoesters; acyl imidazoles ... See more keywords