An umpolung reaction of α-iminonitriles and its application to the synthesis of aminomalononitriles
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DOI: 10.1039/c9nj05114g
Abstract: An umpolung N-alkylation reaction of α-iminonitriles with Grignard reagents affords the corresponding N-alkylated α-aminonitriles in good yields. Subsequent oxidation and cyanation of the N-alkylated products proceeds effectively to give aminomalononitriles in good yields, and the… read more here.
Keywords: iminonitriles application; umpolung reaction; application synthesis; reaction ... See more keywords
β-Selective One-Pot Synthesis of Acyl-C-Glycosides via Corey–Seebach Umpolung Reaction
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DOI: 10.1055/s-0039-1690158
Abstract: C-Glycosides are commonly used as carbohydrate mimics in drug development due to their stability against enzymatic and chemical hydrolysis. In this Synpacts article we elaborate on our fast and efficient β-selective approach towards protected and… read more here.
Keywords: umpolung reaction; corey seebach; acyl; acyl glycosides ... See more keywords
Mechanistic Pathways in Cyanide-Mediated Benzoin Condensation: A Comprehensive Electron Localisation Function (ELF) and Catastrophe Theory Analysis of the Umpolung Reaction
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DOI: 10.3390/molecules30020378
Abstract: This research investigates the mechanism of the cyanide-type umpolung reaction in benzoin condensation using topological analysis of ELF and catastrophe theory. The study achieves a comprehensive understanding of the evolution of chemical bonds and non-bonding… read more here.
Keywords: reaction; benzoin condensation; umpolung reaction; analysis ... See more keywords