Umpolung Synthesis of 1,3-Amino Alcohols: Stereoselective Addition of 2-Azaallyl Anions to Epoxides.
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DOI: 10.1021/acs.orglett.7b01471
Abstract: We report the direct preparation of 1,3-amino alcohols that contain up to three contiguous stereogenic centers by the umpolung coupling of imines and epoxides. Nucleophilic 2-azaallyl anions, generated from imines, are stereoselectively added to epoxides… read more here.
Keywords: amino; synthesis amino; umpolung synthesis; alcohols stereoselective ... See more keywords
Decarboxylative Umpolung Synthesis of Amines from Carbonyl Compounds
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DOI: 10.1055/s-0040-1707157
Abstract: 2-Azaallyl anions are valuable intermediates which have versatile applications in functionalization with various electrophiles. Decarboxylation of the imines formed from aromatic aldehydes and α,α-diphenylglycine provides an interesting and efficient way to generate delocalized 2-azaallyl anions,… read more here.
Keywords: amines carbonyl; synthesis amines; decarboxylative umpolung; carbonyl compounds ... See more keywords