Thioallenoates in Catalytic Enantioselective [2+2]-Cycloadditions with Unactivated Alkenes.
Sign Up to like & getrecommendations! Published in 2019 at "Tetrahedron"
DOI: 10.1016/j.tet.2019.04.028
Abstract: The application of thioallenoates to catalytic enantioselective [2+2]-cycloadditions with unactivated alkenes is reported.In many cases, the thioallenoates examined exhibit superior reactivity and selectivity compared to the alkoxy analogs generally used in these cycloadditions. read more here.
Keywords: thioallenoates catalytic; enantioselective cycloadditions; cycloadditions unactivated; catalytic enantioselective ... See more keywords
Access to functionalized pyrrolidones via copper-catalyzed aminooxygenation of unactivated alkenes
Sign Up to like & getrecommendations! Published in 2020 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2019.151540
Abstract: Abstract A simple and efficient copper-catalyzed aminooxygenation of unactivated alkenes with commercially available (2,2,6,6-tetramethylpiperidin-1-yl)-oxyl (TEMPO) as an oxygen source is reported. With this protocol, a variety of functionalized pyrrolidones were obtained in good to excellent… read more here.
Keywords: catalyzed aminooxygenation; unactivated alkenes; aminooxygenation unactivated; copper catalyzed ... See more keywords
Base-Promoted Radical Azofluoromethylation of Unactivated Alkenes.
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DOI: 10.1021/acs.orglett.0c01395
Abstract: The base-induced reaction of aryl diazonium salts with commercially available CF3SO2Na/CF2HSO2Na allows for the generation of the corresponding diazene radicals along with fluoromethyl radicals. The addition of fluoromethyl radicals to alkenes with subsequent diazene trapping… read more here.
Keywords: promoted radical; azofluoromethylation unactivated; azofluoromethylation; unactivated alkenes ... See more keywords
Self-Catalyzed Phototandem Perfluoroalkylation/Cyclization of Unactivated Alkenes: Synthesis of Perfluoroalkyl-Substituted Quinazolinones.
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DOI: 10.1021/acs.orglett.0c04225
Abstract: A novel visible-light-induced radical tandem trifluoromethylation/cyclization of unactivated alkenes with sodium perfluoroalkanesulfinates (Rf = CF3, C3F7, C4F9, C6F13, C8F17) under air atmosphere has been developed. A range of quinazolinones containing unactivated alkene moiety and sodium… read more here.
Keywords: unactivated alkenes; cyclization unactivated; self catalyzed; perfluoroalkyl substituted ... See more keywords
Nickel-Catalyzed Chemo- and Regioselective Benzylarylation of Unactivated Alkenes with o-Bromobenzyl Chlorides.
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DOI: 10.1021/acs.orglett.1c03991
Abstract: Chemo- and regioselectively nickel-catalyzed reductive benzylarylation of unactivated alkenes with o-bromobenzyl chlorides is disclosed herein, in which electrophiles participate through a single-component double-site approach. Moreover, its utility is underscored by the concise synthesis of bioactive… read more here.
Keywords: nickel catalyzed; chemo; benzylarylation unactivated; unactivated alkenes ... See more keywords
Photoinduced Three-Component Carboarylation of Unactivated Alkenes with Protic C(sp3)-H Feedstocks.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c03247
Abstract: A general and mild strategy involving three-component carboarylation of unactivated alkenes with protic C(sp3)-H feedstocks via photoredox catalysis was reported. This catalytic system is compatible with a broad range of unactivated alkenes, cyano-substituted arenes, and… read more here.
Keywords: component carboarylation; sp3 feedstocks; protic sp3; three component ... See more keywords
Visible-Light-Driven Hydroacylation of Unactivated Alkenes Using Readily Available Acyl Donors.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.2c04337
Abstract: Herein, we report visible-light-driven hydroacylation of unactivated alkenes. We employed benzimidazolines as new acyl donors and achieved perfect regioselectivity, high functional-group tolerance, and excellent substrate generality. We also performed mechanistic experiments to elucidate the detailed… read more here.
Keywords: hydroacylation unactivated; light driven; visible light; acyl donors ... See more keywords
Rhodium-Catalyzed Allylic C-H Functionalization of Unactivated Alkenes with α-Diazocarbonyl Compounds.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.2c04356
Abstract: A redox-neutral mild methodology for the allylic C-H alkylation of unactivated alkenes with diazo compounds is demonstrated. The developed protocol is able to bypass the possibility of the cyclopropanation of an alkene upon its reaction… read more here.
Keywords: functionalization unactivated; alkenes diazocarbonyl; catalyzed allylic; rhodium catalyzed ... See more keywords
Directed Nickel-Catalyzed Selective Arylhydroxylation of Unactivated Alkenes under Air.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.3c00085
Abstract: An expeditious and novel nickel-catalyzed selective arylhydroxylation of unactivated alkenes with arylboronic acids was developed. This protocol is compatible with β,γ- and γ,δ-alkene amides, including traditionally challenging internal alkenes, to provide important β-arylethylalcohol scaffolds. The… read more here.
Keywords: arylhydroxylation unactivated; selective arylhydroxylation; nickel catalyzed; unactivated alkenes ... See more keywords
Copper-Catalyzed Hydroxyperfluoroalkylation of Unactivated Alkenes: Access to β-Perfluoroalkyl Alcohols.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.3c00651
Abstract: An expeditious copper-catalyzed three-component hydroxyperfluoroalkylation of unactivated alkenes starting from commercially available perfluoroalkyl iodides and an O2 molecule from air as the oxygen source was developed. The Cu/B2pin2 catalytic system offered a novel pattern for… read more here.
Keywords: perfluoroalkyl; perfluoroalkyl alcohols; copper catalyzed; hydroxyperfluoroalkylation unactivated ... See more keywords
Asymmetric Palladium-Catalyzed Aminochlorination of Unactivated Alkenes.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.3c00771
Abstract: A novel Pd-catalyzed enantioselective aminochlorination of alkenes via a 6-endo cyclization is reported herein, which provides easy access to a wide array of structurally diverse 3-chloropiperidines in good yields with excellent enantioselectivities. Notably, both an… read more here.
Keywords: aminochlorination unactivated; palladium catalyzed; asymmetric palladium; aminochlorination ... See more keywords