Site-Selective Functionalization of Unactivated Allylic C–H Bonds via Direct Deprotonation with KTMP: Application to the Formal Total Synthesis of (+)-Artemisinin from Amorphadiene
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DOI: 10.1021/acs.orglett.2c04145
Abstract: The site-selective functionalization of unactivated allylic C–H bonds via direct deprotonation using KTMP is described. The conversion of amorphadiene to artemisinic alcohol via a simple, highly regioselective deprotonation over 4 other possible allylic sites is… read more here.
Keywords: functionalization unactivated; site selective; allylic bonds; selective functionalization ... See more keywords