Transition Metal-Catalyzed Dicarbofunctionalization of Unactivated Olefins.
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DOI: 10.1002/tcr.201700098
Abstract: Transition metal (TM)-catalyzed difunctionalization of unactivated olefins with two carbon-based entities is a powerful method to construct complex molecular architectures rapidly from simple and readily available feedstock chemicals. While dicarbofunctionalization of unactivated olefins has a… read more here.
Keywords: transition metal; unactivated olefins; dicarbofunctionalization unactivated; metal catalyzed ... See more keywords
Enantioselective Deaminative Alkylation of Amino Acid Derivatives with Unactivated Olefins.
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DOI: 10.1021/jacs.1c12350
Abstract: Herein, we report the first Ni-catalyzed enantioselective deaminative alkylation of amino acid and peptide derivatives with unactivated olefins. Key for success was the discovery of a new sterically encumbered bis(oxazoline) ligand backbone, thus offering a… read more here.
Keywords: enantioselective deaminative; derivatives unactivated; alkylation amino; amino acid ... See more keywords
Intermolecular Organophotocatalytic Cyclopropanation of Unactivated Olefins
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DOI: 10.1021/jacs.2c11680
Abstract: Intermolecular cyclopropanation of mono-, di-, and trisubstituted olefins with α-bromo-β-ketoesters and α-bromomalonates under organophotocatalysis is reported. The reaction displays broad functional group tolerance, including substrates bearing acids, alcohols, halides, ethers, ketones, nitriles, esters, amides, carbamates,… read more here.
Keywords: organophotocatalytic cyclopropanation; cyclopropanation; intermolecular organophotocatalytic; cyclopropanation unactivated ... See more keywords
Palladium-Catalyzed Oxidative Amination of Unactivated Olefins with Primary Aliphatic Amines.
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DOI: 10.1021/jacs.3c02114
Abstract: Direct coupling of unactivated olefins with primary alkylamines is considered to be an efficient but unknown method for the construction of complex amines. Herein we report a catalytic intermolecular oxidative amination of unactivated olefins with… read more here.
Keywords: oxidative amination; unactivated olefins; amination unactivated; primary aliphatic ... See more keywords
Organic photoredox catalytic amino-heteroarylation of unactivated olefins to access distal amino ketones.
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DOI: 10.1039/d1cc07189k
Abstract: Here we describe a metal-free amino-heteroarylation of unactivated olefins via organic photoredox catalysis, providing a concise and efficient approach for the rapid synthesis of various δ (β, ε)-amino ketones under mild conditions. This protocol demonstrates… read more here.
Keywords: amino heteroarylation; organic photoredox; heteroarylation unactivated; photoredox catalytic ... See more keywords