Visible light-induced unactivated δ-C(sp3)-H amination of alcohols catalyzed by iron.
Sign Up to like & getrecommendations! Published in 2022 at "ChemSusChem"
DOI: 10.1002/cssc.202201241
Abstract: An iron-catalyzed remote C(sp 3 )-H amination of aliphatic alcohols through 1,5-hydrogen atom transfer is developed. This protocol provides a method to generate δ-C(sp 3 )-N bonds from primary, secondary, and tertiary alcohols under mild… read more here.
Keywords: light induced; unactivated sp3; iron; induced unactivated ... See more keywords
Ag-Catalyzed Remote Unactivated C(sp3)-H Heteroarylation of Free Alcohols in Water.
Sign Up to like & getrecommendations! Published in 2021 at "Organic letters"
DOI: 10.1021/acs.orglett.0c03944
Abstract: Catalyzed by silver salt, the unactivated C(sp3)-H heteroarylation of free alcohol at the δ position is realized under gentle thermal conditions in water through a radical procedure. Both protonic acids and Lewis acids are found… read more here.
Keywords: unactivated sp3; water; catalyzed remote; heteroarylation free ... See more keywords
Conformational Flexibility as a Tool for Enabling Site-Selective Functionalization of Unactivated sp3 C–O Bonds in Cyclic Acetals
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c04513
Abstract: A dual catalytic manifold that enables site-selective functionalization of unactivated sp3 C–O bonds in cyclic acetals with aryl and alkyl halides is reported. The reaction is triggered by an appropriate σ*–p orbital overlap prior to… read more here.
Keywords: functionalization unactivated; unactivated sp3; site selective; sp3 bonds ... See more keywords
Regioselective Alkylative Cross-Coupling of Remote Unactivated C(sp3)-H Bonds.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.9b07014
Abstract: The functionalization of unactivated C(sp3)-H bonds poses a significant challenge due to their ubiquity and relative similarity in most organic frameworks. Herein, we describe the use of a combined photoredox and nickel catalytic system for… read more here.
Keywords: unactivated sp3; sp3 bonds; alkylative cross; regioselective alkylative ... See more keywords
Minisci reaction of heteroarenes and unactivated C(sp3)-H alkanes via a photogenerated chlorine radical.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical communications"
DOI: 10.1039/d2cc06486c
Abstract: Here, an efficient Minisci reaction of heteroarenes and unactivated C(sp3)-H alkanes was achieved using an inexpensive FeCl3 as a photocatalyst. The photogenerated chlorine radical contributed to the HAT of C-H and subsequently initiated this reaction.… read more here.
Keywords: chlorine radical; heteroarenes unactivated; unactivated sp3; reaction ... See more keywords