Nickel-Catalyzed Negishi Cross-Coupling of Alkyl Halides, Including Unactivated Tertiary Halides, with a Boron-Stabilized Organozinc Reagent.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.3c00051
Abstract: Nickel-catalyzed cross-coupling of unactivated tertiary alkyl electrophiles with alkylmetal reagents is still a challenge. We report herein a nickel-catalyzed Negishi cross-coupling of alkyl halides, including unactivated tertiary halides, with boron-stabilized organozinc reagent BpinCH2ZnI, yielding versatile… read more here.
Keywords: unactivated tertiary; cross coupling; nickel catalyzed; catalyzed negishi ... See more keywords
Stereochemical editing logic powered by the epimerization of unactivated tertiary stereocenters
Sign Up to like & getrecommendations! Published in 2022 at "Science"
DOI: 10.1126/science.add6852
Abstract: The stereoselective synthesis of complex targets requires the precise orchestration of chemical transformations that simultaneously establish the connectivity and spatial orientation of desired bonds. In this work, we describe a complementary paradigm for the synthesis… read more here.
Keywords: configuration; stereochemical editing; carbon hydrogen; unactivated tertiary ... See more keywords