Chemical labeling and proteomics for characterization of unannotated small and alternative open reading frame-encoded polypeptides.
Sign Up to like & getrecommendations! Published in 2023 at "Biochemical Society transactions"
DOI: 10.1042/bst20221074
Abstract: Thousands of unannotated small and alternative open reading frames (smORFs and alt-ORFs, respectively) have recently been revealed in mammalian genomes. While hundreds of mammalian smORF- and alt-ORF-encoded proteins (SEPs and alt-proteins, respectively) affect cell proliferation,… read more here.
Keywords: alt proteins; unannotated small; seps alt; alternative open ... See more keywords
Unannotated small RNA clusters associated with circulating extracellular vesicles detect early stage liver cancer
Sign Up to like & getrecommendations! Published in 2021 at "Gut"
DOI: 10.1136/gutjnl-2021-325036
Abstract: Objective Surveillance tools for early cancer detection are suboptimal, including hepatocellular carcinoma (HCC), and biomarkers are urgently needed. Extracellular vesicles (EVs) have gained increasing scientific interest due to their involvement in tumour initiation and metastasis;… read more here.
Keywords: small rna; extracellular vesicles; unannotated small; cancer ... See more keywords