Development and Validation of a Liquid Chromatography–Tandem Mass Spectrometry (LC-MS/MS) Assay for the Determination of Total and Unbound Ciprofloxacin Concentrations in Human Plasma
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DOI: 10.1097/ftd.0000000000000969
Abstract: Background: Although unbound ciprofloxacin is responsible for antibacterial effects, assays measuring the unbound drug plasma concentrations are scarce. This study aimed to develop and validate a rapid, reproducible, and sensitive liquid chromatography–tandem mass spectrometry assay… read more here.
Keywords: ciprofloxacin; total unbound; plasma; unbound ciprofloxacin ... See more keywords