Predicting the Brain-To-Plasma Unbound Partition Coefficient of Compounds via Formula-Guided Network
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DOI: 10.1021/acs.jcim.5c00590
Abstract: Blood-brain barrier (BBB) permeability plays a crucial role in determining drug efficacy in the brain, with the brain-to-plasma unbound partition coefficient (Kp,uu) recognized as a key parameter of BBB permeability in drug development. However, Kp,uu… read more here.
Keywords: unbound partition; brain plasma; partition coefficient; brain ... See more keywords