Deficiency of unc-51 like kinase 1 (Ulk1) protects against mice traumatic brain injury (TBI) by suppression of p38 and JNK pathway.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.04.154
Abstract: Unc-51 like autophagy activating kinase 1 (Ulk1) is a serine/threonine kinase that plays a key role in regulating autophagy processes. We attempted to investigate the effects of Ulk1 on traumatic brain injury (TBI) progression by… read more here.
Keywords: traumatic brain; jnk; kinase; kinase ulk1 ... See more keywords
Dual roles of ULK1 (unc-51 like autophagy activating kinase 1) in cytoprotection against lipotoxicity
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DOI: 10.1080/15548627.2019.1598751
Abstract: ABSTRACT Saturated fatty acid (SFA)-induced lipotoxicity is caused by the accumulation of reactive oxygen species (ROS), which is associated with damaged mitochondria. Moreover, lipotoxicity is crucial for the progression of nonalcoholic steatohepatitis (NASH). Autophagy is… read more here.
Keywords: protein; lipotoxicity; kinase; ulk1 unc ... See more keywords
Small Molecule Inhibitors for Unc-51-like Autophagy-Activating Kinase Targeting Autophagy in Cancer
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DOI: 10.3390/ijms24020953
Abstract: Autophagy is a cellular process that removes damaged components of cells and recycles them as biochemical building blocks. Autophagy can also be induced to protect cells in response to intra- and extracellular stresses, including damage… read more here.
Keywords: unc like; autophagy cancer; like autophagy; autophagy activating ... See more keywords
Downregulated miR-302d-3p promotes chondrocyte proliferation and migration by regulation of Unc-51-like kinase 1
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Medicine"
DOI: 10.3892/ijmm.2019.4267
Abstract: Osteoarthritis (OA) is a common musculoskeletal disease and is related to the function of chondrocytes. The aim of the present study was to investigate the effects of miR-302d-3p on chondrocytes. Quantitative PCR (qPCR) was conducted… read more here.
Keywords: proliferation migration; like kinase; migration; mir 302d ... See more keywords