Uncarialins A-I, Monoterpenoid Indole Alkaloids from Uncaria rhynchophylla as Natural Agonists of the 5-HT1A Receptor.
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DOI: 10.1021/acs.jnatprod.9b00532
Abstract: Nine new monoterpenoid indole alkaloids, uncarialins A-I (1-9), were isolated from Uncaria rhynchophylla as well as 14 known analogues (10-23). Their structures were determined by HRESIMS, 1D and 2D NMR, and experimental and calculated electronic… read more here.
Keywords: ht1a receptor; uncaria rhynchophylla; indole alkaloids; uncarialins monoterpenoid ... See more keywords
Minor monoterpene derivatives from an aqueous extract of the hook-bearing stem of Uncaria rhynchophylla
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Asian Natural Products Research"
DOI: 10.1080/10286020.2022.2061961
Abstract: Abstract Seven new minor monoterpene derivatives (1–7), together with six known analogues, were isolated from an aqueous decoction of the hook-bearing stems of Uncaria rhynchophylla (Gou-teng). Their structures were determined by spectroscopic data analysis and… read more here.
Keywords: uncaria rhynchophylla; minor monoterpene; monoterpene derivatives; hook bearing ... See more keywords
Mechanisms of Action of Uncaria rhynchophylla Ethanolic Extract for Its Vasodilatory Effects.
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DOI: 10.1089/jmf.2016.3804
Abstract: Uncaria rhynchophylla is one of the major components included in Traditional Chinese Medicine prescriptions for hypertensive treatment. Previous studies have suggested that U. rhynchophylla might contain vasodilation-mediating active compounds, especially indole alkaloids. Hence, this study… read more here.
Keywords: signaling mechanism; mechanism pathways; uncaria rhynchophylla; rhynchophylla ... See more keywords
Profiles of Metabolic Genes in Uncaria rhynchophylla and Characterization of the Critical Enzyme Involved in the Biosynthesis of Bioactive Compounds-(iso)Rhynchophylline
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DOI: 10.3390/biom12121790
Abstract: Rhynchophylline (RIN) and isorhynchophylline (IRN), two of the representative types of indole alkaloids, showed the unique spiroindole structures produced in Uncaria rhynchophylla. As the bioactive constituent of U. rhynchophylla, IRN has recently drawn extensive attention… read more here.
Keywords: rhynchophylline; spiroindole alkaloids; uncaria rhynchophylla; involved biosynthesis ... See more keywords
The Main Alkaloids in Uncaria rhynchophylla and Their Anti-Alzheimer’s Disease Mechanism Determined by a Network Pharmacology Approach
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DOI: 10.3390/ijms22073612
Abstract: Alzheimer’s disease (AD) is a growing concern in modern society, and effective drugs for its treatment are lacking. Uncaria rhynchophylla (UR) and its main alkaloids have been studied to treat neurodegenerative diseases such as AD.… read more here.
Keywords: network; alzheimer disease; uncaria rhynchophylla; pathology ... See more keywords