Human variability in isoform-specific UDP-glucuronosyltransferases: markers of acute and chronic exposure, polymorphisms and uncertainty factors
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DOI: 10.1007/s00204-020-02765-8
Abstract: UDP-glucuronosyltransferases (UGTs) are involved in phase II conjugation reactions of xenobiotics and differences in their isoform activities result in interindividual kinetic differences of UGT probe substrates. Here, extensive literature searches were performed to identify probe… read more here.
Keywords: uncertainty; uncertainty factors; isoform; probe substrates ... See more keywords