Assessing parameter uncertainty in small-n pharmacometric analyses: value of the log-likelihood profiling-based sampling importance resampling (LLP-SIR) technique
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DOI: 10.1007/s10928-020-09682-4
Abstract: Assessing parameter uncertainty is a crucial step in pharmacometric workflows. Small datasets with ten or fewer subjects appear regularly in drug development and therapeutic use, but it is unclear which method to assess parameter uncertainty… read more here.
Keywords: parameter uncertainty; sir; llp sir; uncertainty small ... See more keywords