Design, synthesis and biological evaluation of uncharged catechol derivatives as selective inhibitors of PTP1B.
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DOI: 10.1016/j.ejmech.2017.05.007
Abstract: Protein tyrosine phosphatases 1B (PTP1B) is a promising and validated therapeutic target to effectively treat T2DM and obesity. However, the development of charged PTP1B inhibitors was restricted due to their low cell permeability and poor… read more here.
Keywords: design synthesis; biological evaluation; uncharged catechol; evaluation uncharged ... See more keywords