Liver Injury in Uncomplicated Malaria is an Overlooked Phenomenon: An Observational Study
Sign Up to like & getrecommendations! Published in 2018 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2018.09.018
Abstract: Abstract Background Liver injury is a known feature of severe malaria, but is only incidentally investigated in uncomplicated disease. In such cases, drug-induced hepatotoxicity is often thought to be the primary cause of the observed… read more here.
Keywords: study; chmi; uncomplicated malaria; lft abnormalities ... See more keywords
Molecular surveillance of chloroquine-resistant Plasmodium falciparum in sub-Saharan African countries after withdrawal of chloroquine for treatment of uncomplicated malaria: A systematic review.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of infection and public health"
DOI: 10.1016/j.jiph.2022.03.015
Abstract: BACKGROUND A wide spread of chloroquine resistance prompted its discontinued use for treatment of uncomplicated malaria in several African countries. However, disappearances of chloroquine-resistant parasites have been reported in areas with restricted use of chloroquine.… read more here.
Keywords: review; treatment uncomplicated; falciparum; chloroquine resistant ... See more keywords
Discovery and Preclinical Pharmacology of INE963, a Potent and Fast-Acting Blood-Stage Antimalarial with a High Barrier to Resistance and Potential for Single-Dose Cures in Uncomplicated Malaria
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.1c01995
Abstract: A series of 5-aryl-2-amino-imidazothiadiazole (ITD) derivatives were identified by a phenotype-based high-throughput screening using a blood stage Plasmodium falciparum (Pf) growth inhibition assay. A lead optimization program focused on improving antiplasmodium potency, selectivity against human… read more here.
Keywords: single dose; pharmacology; blood stage; barrier resistance ... See more keywords
Polymorphisms in Plasmodium falciparum dihydropteroate synthetase and dihydrofolate reductase genes in Nigerian children with uncomplicated malaria using high-resolution melting technique
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-020-80017-6
Abstract: In 2005, the Nigerian Federal Ministry of Health revised the treatment policy for uncomplicated malaria with the introduction of artemisinin-based combination therapies (ACTs). This policy change discouraged the use of Sulphadoxine-pyrimethamine (SP) as the second-line… read more here.
Keywords: dhps; high resolution; dihydropteroate synthetase; resolution melting ... See more keywords
Post-treatment haemolysis is common following oral artemisinin combination therapy of uncomplicated malaria in travellers
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Travel Medicine"
DOI: 10.1093/jtm/taad001
Abstract: Abstract Background Artemisinin-based combination therapy (ACT) for the treatment of malaria is highly effective, well tolerated and safe. Episodes of delayed haemolysis occur in up to 57.9% of patients with severe malaria treated with intravenous… read more here.
Keywords: treatment haemolysis; post treatment; combination therapy; treatment ... See more keywords
EFFICACY AND TOLERABILITY OF REPEATED ADMINISTRATION OF ACTS OVER A PERIOD OF TWO YEARS IN CHILDREN AND ADULT PATIENTS WITH ACUTE UNCOMPLICATED MALARIA IN BURKINA FASO
Sign Up to like & getrecommendations! Published in 2017 at "BMJ Global Health"
DOI: 10.1136/bmjgh-2016-000260.48
Abstract: Background According to the guidelines of the Burkina Faso National Malaria Control Programme, artesunate-amodiaquine (ASAQ) and artemether-lumefantrine (AL) are the first-line drugs for uncomplicated malaria treatments. However, in some contexts where individuals will experience more… read more here.
Keywords: burkina faso; malaria; uncomplicated malaria; day ... See more keywords
Safety and tolerability of adjunctive rosiglitazone treatment for children with uncomplicated malaria
Sign Up to like & getrecommendations! Published in 2017 at "Malaria Journal"
DOI: 10.1186/s12936-017-1858-0
Abstract: BackgroundDespite the widespread use and availability of rapidly acting anti-malarials, the fatality rate of severe malaria in sub-Saharan Africa remains high. Adjunctive therapies that target the host response to malaria infection may further decrease mortality… read more here.
Keywords: treatment; safety; tolerability; children uncomplicated ... See more keywords
Economic costs analysis of uncomplicated malaria case management in the Peruvian Amazon
Sign Up to like & getrecommendations! Published in 2020 at "Malaria Journal"
DOI: 10.1186/s12936-020-03233-5
Abstract: Background Case management is one of the principal strategies for malaria control. This study aimed to estimate the economic costs of uncomplicated malaria case management and explore the influence of health-seeking behaviours on those costs.… read more here.
Keywords: case management; cost; uncomplicated malaria; episode ... See more keywords
Hepatic safety of repeated treatment with pyronaridine‐artesunate versus artemether–lumefantrine in patients with uncomplicated malaria: a secondary analysis of the WANECAM 1 data from Bobo-Dioulasso, Burkina Faso
Sign Up to like & getrecommendations! Published in 2021 at "Malaria Journal"
DOI: 10.1186/s12936-021-03593-6
Abstract: Background The use of pyronaridine-artesunate (PA) has been associated with scarce transaminitis in patients. This analysis aimed to evaluate the hepatic safety profile of repeated treatment with PA versus artemether–lumefantrine (AL) in patients with consecutive… read more here.
Keywords: artemether lumefantrine; pyronaridine artesunate; hepatic safety; uncomplicated malaria ... See more keywords
Therapeutic efficacy of dihydroartemisinin-piperaquine combination for the treatment of uncomplicated malaria in Ghana
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2022.1058660
Abstract: In 2020, Dihydroartemisinin-Piperaquine (DHAP) was adopted as a second-line antimalarial for treatment of uncomplicated malaria in Ghana following a review of the country’s antimalarial medicines policy. Available data obtained in 2007 had shown PCR-uncorrected therapeutic… read more here.
Keywords: day; uncomplicated malaria; efficacy; malaria ghana ... See more keywords
Low Interleukin-12 Levels concerning Severe Malaria: A Systematic Review and Meta-Analysis
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Environmental Research and Public Health"
DOI: 10.3390/ijerph19159345
Abstract: Although many studies have investigated the role of interleukin (IL)-12 cytokine in the pathogenesis of severe malaria, these studies were based on a limited number of participants, possibly affecting their outcomes. We analyzed the difference… read more here.
Keywords: meta analysis; severe malaria; patients severe; systematic review ... See more keywords