Efficacy, safety, and tolerability of lebrikizumab in adolescent patients with uncontrolled asthma (ACOUSTICS)
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and Translational Allergy"
DOI: 10.1002/clt2.12176
Abstract: Abstract Background Lebrikizumab is a monoclonal antibody that modulates activity of interleukin‐13. The Phase 3 ACOUSTICS study assessed lebrikizumab efficacy and safety in adolescents with uncontrolled asthma despite standard‐of‐care treatment. Methods Adolescents (aged 12–17 years)… read more here.
Keywords: acoustics; lebrikizumab 125; rate; efficacy safety ... See more keywords
Oxidative stress in patients with asthma and its relation to uncontrolled asthma.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of clinical laboratory analysis"
DOI: 10.1002/jcla.24345
Abstract: This study aims to evaluate markers of oxidative stress in Tunisian asthmatic patients and investigate whether their markers are correlated with uncontrolled asthma. This prospective cohort study was conducted on 48 healthy subjects and 60 patients… read more here.
Keywords: asthmatic patients; patients asthma; oxidative stress; activity ... See more keywords
External validation can provide the clinician with IOS equations that best predict the risk of uncontrolled asthma in their population
Sign Up to like & getrecommendations! Published in 2022 at "Pediatric Pulmonology"
DOI: 10.1002/ppul.26170
Abstract: Peripheral airway impairment (PAI) has been shown to have a close association to risk of uncontrolled asthma in children. However, clear methods have not been established for the clinician to select impulse oscillometry (IOS) reference… read more here.
Keywords: equations best; external validation; risk uncontrolled; population ... See more keywords
Children with uncontrolled asthma from economically disadvantaged neighborhoods: Needs assessment and the development of a school-based telehealth and electronic inhaler monitoring system.
Sign Up to like & getrecommendations! Published in 2023 at "Pediatric pulmonology"
DOI: 10.1002/ppul.26457
Abstract: BACKGROUND Children from economically disadvantaged communities often encounter healthcare access barriers, increasing risk for poorly controlled asthma and subsequent healthcare utilization. This highlights the need to identify novel intervention strategies for these families. OBJECTIVE To… read more here.
Keywords: economically disadvantaged; development; needs assessment; school ... See more keywords
Uncontrolled asthma occurs in all GINA treatment steps and is associated with worse physical health – a report from the OLIN adult asthma cohort
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Asthma"
DOI: 10.1080/02770903.2020.1713150
Abstract: Abstract Objective: To study asthma exacerbations, healthcare utilization and health status among subjects with asthma with different treatment regimens and levels of asthma control. Methods: In 2012–2014, n = 1425 adults from a population-based asthma cohort within… read more here.
Keywords: treatment steps; exacerbations healthcare; treatment; uncontrolled asthma ... See more keywords
Fibromyalgia as a cause of uncontrolled asthma: a case–control multicenter study
Sign Up to like & getrecommendations! Published in 2017 at "Current Medical Research and Opinion"
DOI: 10.1080/03007995.2017.1354828
Abstract: Abstract Background: Fibromyalgia can affect the control of asthma when both diseases are present in a single patient. Objectives: To characterize asthma in patients with concomitant fibromyalgia to assess whether fibromyalgia is an independent factor… read more here.
Keywords: multicenter study; control; control multicenter; uncontrolled asthma ... See more keywords
Umeclidinium for the treatment of uncontrolled asthma
Sign Up to like & getrecommendations! Published in 2017 at "Expert Opinion on Investigational Drugs"
DOI: 10.1080/13543784.2017.1319472
Abstract: ABSTRACT Introduction: Smooth muscle cell contraction in the airways is the principal therapeutic target in asthmatic subjects and its insufficient treatment is often a cause of uncontrolled disease. For this reason, research has focused on… read more here.
Keywords: treatment uncontrolled; treatment; umeclidinium treatment; uncontrolled asthma ... See more keywords
Tezepelumab: a novel biological therapy for the treatment of severe uncontrolled asthma
Sign Up to like & getrecommendations! Published in 2019 at "Expert Opinion on Investigational Drugs"
DOI: 10.1080/13543784.2019.1672657
Abstract: ABSTRACT Introduction: Thymic stromal lymphopoietin (TSLP) is overexpressed in the airways of severe asthmatics and is an upstream cytokine that orchestrates inflammatory responses in asthma. TSLP exerts its effects by binding to a high affinity… read more here.
Keywords: therapy; severe uncontrolled; uncontrolled asthma; tezepelumab ... See more keywords
Pharmacogenetics of childhood uncontrolled asthma.
Sign Up to like & getrecommendations! Published in 2023 at "Expert review of clinical immunology"
DOI: 10.1080/1744666x.2023.2214363
Abstract: INTRODUCTION Asthma is a heterogenous, multifactorial disease with multiple genetic and environmental risk factors playing a role in pathogenesis and therapeutic response. Understanding of pharmacogenetics can help with matching individualized treatments to specific genotypes of… read more here.
Keywords: childhood uncontrolled; asthma; pharmacogenetics childhood; uncontrolled asthma ... See more keywords
IL-26 in asthma and COPD.
Sign Up to like & getrecommendations! Published in 2022 at "Expert review of respiratory medicine"
DOI: 10.1080/17476348.2022.2045197
Abstract: INTRODUCTION New targets are needed to enable more accurate diagnosis, monitoring and effective therapy in uncontrolled asthma and chronic obstructive pulmonary disease (COPD), two disorders characterized by pathogenic alterations in the innate immune response. Interestingly,… read more here.
Keywords: medicine; copd; immunology; asthma copd ... See more keywords
Electronic nose: a pilot study to discriminate of children with uncontrolled asthma.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of breath research"
DOI: 10.1088/1752-7163/ab9ab0
Abstract: BACKGROUND Measuring biomarkers (e.g., volatile organic compounds [VOCs]) in exhaled breath is an attractive approach to monitor airway inflammation in asthma and other lung diseases. E-Nose technology has been studied to identify VOCs in exhaled… read more here.
Keywords: electronic nose; children uncontrolled; uncontrolled asthma; exhaled breath ... See more keywords