Roads and hubs of unconventional protein secretion.
Sign Up to like & getrecommendations! Published in 2022 at "Current opinion in cell biology"
DOI: 10.1016/j.ceb.2022.02.006
Abstract: In eukaryotes, there is now compelling evidence that in addition to the conventional endoplasmic reticulum-Golgi secretory pathway, there are additional routes for the export of cytoplasmic proteins with a critical role in numerous physio-pathological conditions.… read more here.
Keywords: hubs unconventional; roads hubs; protein secretion; unconventional protein ... See more keywords
Secretomics—A Key to a Comprehensive Picture of Unconventional Protein Secretion
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.878027
Abstract: For a long time, leaderless secreted proteins (LLSP) were neglected as artifacts derived from dying cells. It is now generally accepted that secretion of LLSP–as a part of the collective term unconventional protein secretion (UPS)… read more here.
Keywords: comprehensive picture; secretion; unconventional protein; protein secretion ... See more keywords
Autophagy-Related Pathways in Vesicular Unconventional Protein Secretion
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.892450
Abstract: Cellular proteins directed to the plasma membrane or released into the extracellular space can undergo a number of different pathways. Whereas the molecular mechanisms that underlie conventional ER-to-Golgi trafficking are well established, those associated with… read more here.
Keywords: autophagy related; related pathways; protein secretion; unconventional protein ... See more keywords
Safeguarding Lysosomal Homeostasis by DNAJC5/CSPα-Mediated Unconventional Protein Secretion and Endosomal Microautophagy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.906453
Abstract: Neuronal ceroid lipofuscinosis (NCL) is a collection of genetically inherited neurological disorders characterized by vision loss, seizure, brain death, and premature lethality. At the cellular level, a key pathologic hallmark of NCL is the build-up… read more here.
Keywords: lysosomal homeostasis; dnajc5 csp; endosomal microautophagy; unconventional protein ... See more keywords
Facets of Autophagy Based Unconventional Protein Secretion–The Road Less Traveled
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2020.586483
Abstract: Unconventional protein secretion (UCPS) of leaderless proteins bypasses the conventional endoplasmic reticulum (ER)-Golgi route. The proportion of UCPS in the secretome varies tremendously across eukaryotes. Interestingly, macroautophagy, an intracellular recycling process that is generally involved… read more here.
Keywords: unconventional protein; facets autophagy; autophagy based; protein secretion ... See more keywords
The Universally Conserved Unconventional G Protein YchF Is Critical for Growth and Stress Response
Sign Up to like & getrecommendations! Published in 2023 at "Life"
DOI: 10.3390/life13041058
Abstract: The ancient guanine nucleotide-binding (G) proteins are a group of critical regulatory and signal transduction proteins, widely involved in diverse cellular processes of all kingdoms of life. YchF is a kind of universally conserved novel… read more here.
Keywords: stress; growth; unconventional protein; response ... See more keywords