Unconventional secretion: cargo channeling by TMED10
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DOI: 10.1038/s41422-020-0382-x
Abstract: Cytosolic proteins lacking a signal peptide are often loaded into vesicles and secreted via unconventional protein secretion pathways. A recent paper in Cell identifies the transmembrane protein TMED10 as a protein channel for the vesicular… read more here.
Keywords: unconventional secretion; protein; secretion; mil ... See more keywords
Early Bioinformatic Implication of Triacidic Amino Acid Motifs in Autophagy-Dependent Unconventional Secretion of Mammalian Proteins
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.863825
Abstract: Several proteins are secreted outside the cell, and in many cases, they may be identified by a characteristic signal peptide. However, more and more studies point to the evidence for an “unconventional” secretion, where proteins… read more here.
Keywords: unconventional secretion; triacidic amino; secretion; amino acid ... See more keywords
Prelysosomal Compartments in the Unconventional Secretion of Amyloidogenic Seeds
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DOI: 10.3390/ijms18010227
Abstract: A mechanistic link between neuron-to-neuron transmission of secreted amyloid and propagation of protein malconformation cytopathology and disease has recently been uncovered in animal models. An enormous interest in the unconventional secretion of amyloids from neurons… read more here.
Keywords: unconventional secretion; amyloidogenic seeds; compartments unconventional; secretion ... See more keywords
Key steps in unconventional secretion of fibroblast growth factor 2 reconstituted with purified components
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DOI: 10.7554/elife.28985
Abstract: FGF2 is secreted from cells by an unconventional secretory pathway. This process is mediated by direct translocation across the plasma membrane. Here, we define the minimal molecular machinery required for FGF2 membrane translocation in a… read more here.
Keywords: unconventional secretion; fgf2; translocation; membrane ... See more keywords