Specific Interaction of the Human Mitochondrial Uncoupling Protein 1 with Free Long-Chain Fatty Acid.
Sign Up to like & getrecommendations! Published in 2017 at "Structure"
DOI: 10.1016/j.str.2017.07.005
Abstract: The mitochondrial uncoupling protein 1 (UCP1) generates heat by causing proton leak across the mitochondrial inner membrane that requires fatty acid (FA). The mechanism by which UCP1 uses FA to conduct proton remains unsolved, and… read more here.
Keywords: chain; mitochondrial uncoupling; specific interaction; fatty acid ... See more keywords
Fibroblast growth factor 8b induces uncoupling protein 1 expression in epididymal white preadipocytes
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-44878-w
Abstract: The number of brown adipocytes residing within murine white fat depots (brite adipocytes) varies a lot by depot, strain and physiological condition. Several endocrine fibroblast growth factors are implicated in the regulation of brite adipocyte… read more here.
Keywords: fibroblast growth; growth factor; epididymal white; uncoupling protein ... See more keywords
Emerging role and the signaling pathways of uncoupling protein 2 in kidney diseases
Sign Up to like & getrecommendations! Published in 2024 at "Renal Failure"
DOI: 10.1080/0886022x.2024.2381604
Abstract: Abstract Objectives Uncoupling protein 2 (UCP2) was involved in the pathogenesis and development of kidney diseases. Many signaling pathways and factors regulate the expression of UCP2. We aimed to investigate the precise role of UCP2… read more here.
Keywords: signaling pathways; role; kidney diseases; uncoupling protein ... See more keywords
Structural basis of purine nucleotide inhibition of human uncoupling protein 1.
Sign Up to like & getrecommendations! Published in 2023 at "Science advances"
DOI: 10.1126/sciadv.adh4251
Abstract: Mitochondrial uncoupling protein 1 (UCP1) gives brown adipose tissue of mammals its specialized ability to burn calories as heat for thermoregulation. When activated by fatty acids, UCP1 catalyzes the leak of protons across the mitochondrial… read more here.
Keywords: uncoupling protein; purine; structural basis; basis purine ... See more keywords
Uncoupling Protein 2: A Key Player and a Potential Therapeutic Target in Vascular Diseases
Sign Up to like & getrecommendations! Published in 2017 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2017/7348372
Abstract: Uncoupling protein 2 (UCP2) is an inner mitochondrial membrane protein that belongs to the uncoupling protein family and plays an important role in lowering mitochondrial membrane potential and dissipating metabolic energy with prevention of oxidative… read more here.
Keywords: protein; player; uncoupling protein; vascular diseases ... See more keywords
Abstract 4830: Uncoupling protein 2 (UCP2) loss of function mediates PDAC tumor suppression by mitochondrial fusion
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4830
Abstract: Background: Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer with a dependence on highly active mitochondria to grow and metastasize. We previously found that mitochondrial fusion suppressed PDAC growth and metastasis, leading to improved survival… read more here.
Keywords: fusion; uncoupling protein; protein ucp2; mitochondrial fusion ... See more keywords
Mitochondrial uncoupling protein 2: a central player in pancreatic disease pathophysiology
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Medicine"
DOI: 10.1186/s10020-024-01027-y
Abstract: Pancreatic diseases pose considerable health challenges due to their complex etiology and limited therapeutic options. Mitochondrial uncoupling protein 2 (UCP2), highly expressed in pancreatic tissue, participates in numerous physiological processes and signaling pathways, indicating its… read more here.
Keywords: disease; mitochondrial uncoupling; uncoupling protein; pancreatic disease ... See more keywords
Keys to the switch of fat burning: stimuli that trigger the uncoupling protein 1 (UCP1) activation in adipose tissue
Sign Up to like & getrecommendations! Published in 2024 at "Lipids in Health and Disease"
DOI: 10.1186/s12944-024-02300-z
Abstract: As one of the main pathogenic factors of cardiovascular and cerebrovascular diseases, the incidence of metabolic diseases such as adiposity and metabolic dysfunction-associated steatotic liver disease (MASLD) is increasing annually. It is urgent and crucial… read more here.
Keywords: thermogenesis; uncoupling protein; protein ucp1; adipose tissue ... See more keywords
Association of 45-bp ins/del polymorphism of uncoupling protein 2 (UCP2) and susceptibility to nonalcoholic fatty liver and type 2 diabetes mellitus in North-west of Iran
Sign Up to like & getrecommendations! Published in 2021 at "BMC Research Notes"
DOI: 10.1186/s13104-021-05586-9
Abstract: Objective Uncoupling protein 2 (UCP2) plays a crucial role in energy homeostasis via insulin secretion regulation, free fatty acid concentrations, and lipid metabolism. This study aimed to investigate the association of 45-bp ins/del polymorphism of… read more here.
Keywords: del polymorphism; protein ucp2; ins del; uncoupling protein ... See more keywords
Downregulation of Uncoupling Protein 2(UCP2) Mediated by MicroRNA-762 Confers Cardioprotection and Participates in the Regulation of Dynamic Mitochondrial Homeostasis of Dynamin Related Protein1 (DRP1) After Myocardial Infarction in Mice
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2021.764064
Abstract: Acute myocardial infarction (MI) is one of the leading causes of death in the world, and its pathophysiological mechanisms have not been fully elucidated. The purpose of this study was to investigate the role and… read more here.
Keywords: drp1; apoptosis; uncoupling protein; myocardial infarction ... See more keywords
Uncoupling Protein 2 in Cardiovascular Health and Disease
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2018.01060
Abstract: Uncoupling protein 2 (UCP2) belongs to the family of mitochondrial anion carrier proteins. It uncouples oxygen consumption from ATP synthesis. UCP2 is ubiquitously expressed in most cell types to reduce oxidative stress. It is tightly… read more here.
Keywords: ucp2 expression; dysfunction; stress; uncoupling protein ... See more keywords