Specific Interaction of the Human Mitochondrial Uncoupling Protein 1 with Free Long-Chain Fatty Acid.
Sign Up to like & getrecommendations! Published in 2017 at "Structure"
DOI: 10.1016/j.str.2017.07.005
Abstract: The mitochondrial uncoupling protein 1 (UCP1) generates heat by causing proton leak across the mitochondrial inner membrane that requires fatty acid (FA). The mechanism by which UCP1 uses FA to conduct proton remains unsolved, and… read more here.
Keywords: chain; mitochondrial uncoupling; specific interaction; fatty acid ... See more keywords
Fibroblast growth factor 8b induces uncoupling protein 1 expression in epididymal white preadipocytes
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-44878-w
Abstract: The number of brown adipocytes residing within murine white fat depots (brite adipocytes) varies a lot by depot, strain and physiological condition. Several endocrine fibroblast growth factors are implicated in the regulation of brite adipocyte… read more here.
Keywords: fibroblast growth; growth factor; epididymal white; uncoupling protein ... See more keywords
Structural basis of purine nucleotide inhibition of human uncoupling protein 1.
Sign Up to like & getrecommendations! Published in 2023 at "Science advances"
DOI: 10.1126/sciadv.adh4251
Abstract: Mitochondrial uncoupling protein 1 (UCP1) gives brown adipose tissue of mammals its specialized ability to burn calories as heat for thermoregulation. When activated by fatty acids, UCP1 catalyzes the leak of protons across the mitochondrial… read more here.
Keywords: uncoupling protein; purine; structural basis; basis purine ... See more keywords
Uncoupling Protein 2: A Key Player and a Potential Therapeutic Target in Vascular Diseases
Sign Up to like & getrecommendations! Published in 2017 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2017/7348372
Abstract: Uncoupling protein 2 (UCP2) is an inner mitochondrial membrane protein that belongs to the uncoupling protein family and plays an important role in lowering mitochondrial membrane potential and dissipating metabolic energy with prevention of oxidative… read more here.
Keywords: protein; player; uncoupling protein; vascular diseases ... See more keywords
Abstract 4830: Uncoupling protein 2 (UCP2) loss of function mediates PDAC tumor suppression by mitochondrial fusion
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4830
Abstract: Background: Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer with a dependence on highly active mitochondria to grow and metastasize. We previously found that mitochondrial fusion suppressed PDAC growth and metastasis, leading to improved survival… read more here.
Keywords: fusion; uncoupling protein; protein ucp2; mitochondrial fusion ... See more keywords
Association of 45-bp ins/del polymorphism of uncoupling protein 2 (UCP2) and susceptibility to nonalcoholic fatty liver and type 2 diabetes mellitus in North-west of Iran
Sign Up to like & getrecommendations! Published in 2021 at "BMC Research Notes"
DOI: 10.1186/s13104-021-05586-9
Abstract: Objective Uncoupling protein 2 (UCP2) plays a crucial role in energy homeostasis via insulin secretion regulation, free fatty acid concentrations, and lipid metabolism. This study aimed to investigate the association of 45-bp ins/del polymorphism of… read more here.
Keywords: del polymorphism; protein ucp2; ins del; uncoupling protein ... See more keywords
Downregulation of Uncoupling Protein 2(UCP2) Mediated by MicroRNA-762 Confers Cardioprotection and Participates in the Regulation of Dynamic Mitochondrial Homeostasis of Dynamin Related Protein1 (DRP1) After Myocardial Infarction in Mice
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2021.764064
Abstract: Acute myocardial infarction (MI) is one of the leading causes of death in the world, and its pathophysiological mechanisms have not been fully elucidated. The purpose of this study was to investigate the role and… read more here.
Keywords: drp1; apoptosis; uncoupling protein; myocardial infarction ... See more keywords
Uncoupling Protein 2 in Cardiovascular Health and Disease
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2018.01060
Abstract: Uncoupling protein 2 (UCP2) belongs to the family of mitochondrial anion carrier proteins. It uncouples oxygen consumption from ATP synthesis. UCP2 is ubiquitously expressed in most cell types to reduce oxidative stress. It is tightly… read more here.
Keywords: ucp2 expression; dysfunction; stress; uncoupling protein ... See more keywords
Relationships between Uncoupling Protein Genes UCP1, UCP2 and UCP3 and Irisin Levels in Residents of the Coldest Region of Siberia
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.3390/genes13091612
Abstract: Currently, it is known that irisin can participate in the processes of thermoregulation and browning of adipose tissue, and, therefore, it is possible that it is involved in the microevolutionary mechanisms of adaptation to a… read more here.
Keywords: irisin; ucp1 ucp2; uncoupling protein; protein genes ... See more keywords
Brain Overexpression of Uncoupling Protein-2 (UCP2) Delays Renal Damage and Stroke Occurrence in Stroke-Prone Spontaneously Hypertensive Rats
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21124289
Abstract: The downregulation of uncoupling protein-2 (UCP2) is associated with increased brain and kidney injury in stroke-prone spontaneously hypertensive rats (SHRSP) fed with a Japanese style hypersodic diet (JD). Systemic overexpression of UCP2 reduces organ damage… read more here.
Keywords: overexpression; protein ucp2; occurrence; uncoupling protein ... See more keywords
Uncoupling Protein 1 Does Not Produce Heat without Activation
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23052406
Abstract: Mitochondrial uncoupling protein 1 (UCP1) is the crucial mechanistic component of heat production in classical brown fat and the newly identified beige or brite fat. Thermogenesis inevitably comes at a high energetic cost and brown… read more here.
Keywords: brown fat; without activation; uncoupling protein; heat ... See more keywords