LAUSR

Underground metabolism facilitates the evolution of novel pathways for vitamin B6 biosynthesis

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0 Published in 2021 at "Applied Microbiology and Biotechnology"

DOI: 10.1007/s00253-021-11199-w

Abstract: Abstract The term vitamin B6 is a designation for the vitamers pyridoxal, pyridoxamine, pyridoxine and the respective phosphate esters pyridoxal-5′-phosphate (PLP), pyridoxamine-5′-phosphate and pyridoxine-5′-phosphate. Animals and humans are unable to synthesise vitamin B6. These organisms… read more here.

Keywords: vitamin; metabolism facilitates; underground metabolism; vitamin biosynthesis ... See more keywords

Underground metabolism: network-level perspective and biotechnological potential.

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0 Published in 2018 at "Current opinion in biotechnology"

DOI: 10.1016/j.copbio.2017.07.015

Abstract: A key challenge in molecular systems biology is understanding how new pathways arise during evolution and how to exploit them for biotechnological applications. New pathways in metabolic networks often evolve by recruiting weak promiscuous activities… read more here.

Keywords: underground metabolism; metabolism network; metabolism; level perspective ... See more keywords

Underground metabolism as a rich reservoir for pathway engineering.

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1 Published in 2022 at "Bioinformatics"

DOI: 10.1093/bioinformatics/btac282

Abstract: MOTIVATION Bioproduction of value-added compounds is frequently achieved by utilizing enzymes from other species. However, expression of such heterologous enzymes can be detrimental due to unexpected interactions within the host cell. Recently, an alternative strategy… read more here.

Keywords: reservoir pathway; engineering; pathway engineering; underground metabolism ... See more keywords

Systems-Wide Dissection of Organic Acid Assimilation in Pseudomonas aeruginosa Reveals a Novel Path To Underground Metabolism

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1 Published in 2022 at "mBio"

DOI: 10.1128/mbio.02541-22

Abstract: Pseudomonas aeruginosa is an opportunistic human pathogen that, due to its unrivalled resistance to antibiotics, ubiquity in the built environment, and aggressiveness in infection scenarios, has acquired the somewhat dubious accolade of being designated a… read more here.

Keywords: metabolism; synthase; pseudomonas aeruginosa; infection ... See more keywords