Cellular secretion and cytotoxicity of transthyretin mutant proteins underlie late-onset amyloidosis and neurodegeneration
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DOI: 10.1007/s00018-019-03357-1
Abstract: Transthyretin amyloidosis (ATTR) is a progressive life-threatening disease characterized by the deposition of transthyretin (TTR) amyloid fibrils. Several pathogenic variants have been shown to destabilize TTR tetramers, leading to aggregation of misfolded TTR fibrils. However,… read more here.
Keywords: late onset; ttr; amyloidosis; underlie late ... See more keywords