Unique transcriptional profiles underlie osteosarcomagenesis driven by different p53 mutants.
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DOI: 10.1158/0008-5472.can-22-3464
Abstract: Missense mutations in the DNA binding domain of p53 are characterized as structural or contact mutations based on their effect on the conformation of the protein. These mutations show gain-of-function activities, such as promoting increased… read more here.
Keywords: profiles underlie; p53 mutants; underlie osteosarcomagenesis; transcriptional profiles ... See more keywords