Network pharmacology reveals potential functional components and underlying molecular mechanisms of Andrographis paniculata in esophageal cancer treatment
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7411
Abstract: Antitumor and antimetastatic effects of the medicinal herb Andrographis paniculata (AP) in esophageal cancer (EC) have been previously reported. In this study, we aimed to uncover the potential functional components and the underlying molecular mechanisms… read more here.
Keywords: pharmacology; functional components; molecular mechanisms; underlying molecular ... See more keywords
The clinical course of actinic keratosis correlates with underlying molecular mechanisms
Sign Up to like & getrecommendations! Published in 2019 at "British Journal of Dermatology"
DOI: 10.1111/bjd.18338
Abstract: Actinic keratoses (AKs) are common premalignant skin lesions triggered by excessive ultraviolet exposure. The majority of AKs regress or persist, but some progress to squamous cell carcinomas. Biomarkers associated with their persistence, progression and regression… read more here.
Keywords: underlying molecular; keratosis correlates; clinical course; course actinic ... See more keywords
Bridging between material properties of proteins and the underlying molecular interactions
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DOI: 10.1371/journal.pone.0247147
Abstract: In this work, we develop a novel method that bridges between material properties of proteins, particularly the modulus of elasticity, and the underlying molecular interactions. To this end, we employ both an all-atom normal mode… read more here.
Keywords: underlying molecular; young moduli; properties proteins; molecular interactions ... See more keywords
MicroRNAs in tear fluids predict underlying molecular changes associated with Alzheimer’s disease
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DOI: 10.26508/lsa.202201757
Abstract: This study demonstrated the translational potential of deregulated tear fluid miRNAs associated with amyloid beta production and proinflammation in a transgenic AD mouse model. Extracellular circulating microRNAs (miRNAs) have been discussed as potential biomarkers for… read more here.
Keywords: disease; alzheimer disease; mirnas associated; expression levels ... See more keywords
Axonal Regeneration: Underlying Molecular Mechanisms and Potential Therapeutic Targets
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DOI: 10.3390/biomedicines10123186
Abstract: Axons in the peripheral nervous system have the ability to repair themselves after damage, whereas axons in the central nervous system are unable to do so. A common and important characteristic of damage to the… read more here.
Keywords: regeneration; axonal regeneration; regeneration underlying; molecular mechanisms ... See more keywords
RNA-Seq Reveals the Underlying Molecular Mechanism of First Cleavage Time Affecting Porcine Embryo Development
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DOI: 10.3390/genes13071251
Abstract: The selection and evaluation of high-quality embryos are the key factors affecting in vitro embryo development and pregnancy outcome. The timing of first embryonic cleavage has been considered a positive indicator of the in vitro… read more here.
Keywords: cleavage; development; embryo development; underlying molecular ... See more keywords