Network pharmacology reveals potential functional components and underlying molecular mechanisms of Andrographis paniculata in esophageal cancer treatment
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7411
Abstract: Antitumor and antimetastatic effects of the medicinal herb Andrographis paniculata (AP) in esophageal cancer (EC) have been previously reported. In this study, we aimed to uncover the potential functional components and the underlying molecular mechanisms… read more here.
Keywords: pharmacology; functional components; molecular mechanisms; underlying molecular ... See more keywords
Insight into the Underlying Molecular Toxic Mechanisms of Cyantraniliprole and Broflanilide against Different Targets with Glutathione Transferase Phi8 from Arabidopsis thaliana.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.4c12417
Abstract: As two typical kinds of diamide insecticides, cyantraniliprole and broflanilide are characterized by diverse target receptors and completely distinctive regulation mechanisms. However, the systematical evaluation of oxidative damage on plants induced by cyantraniliprole and broflanilide… read more here.
Keywords: glutathione transferase; underlying molecular; molecular toxic; insight underlying ... See more keywords
The clinical course of actinic keratosis correlates with underlying molecular mechanisms
Sign Up to like & getrecommendations! Published in 2019 at "British Journal of Dermatology"
DOI: 10.1111/bjd.18338
Abstract: Actinic keratoses (AKs) are common premalignant skin lesions triggered by excessive ultraviolet exposure. The majority of AKs regress or persist, but some progress to squamous cell carcinomas. Biomarkers associated with their persistence, progression and regression… read more here.
Keywords: underlying molecular; keratosis correlates; clinical course; course actinic ... See more keywords
Bridging between material properties of proteins and the underlying molecular interactions
Sign Up to like & getrecommendations! Published in 2021 at "PLoS ONE"
DOI: 10.1371/journal.pone.0247147
Abstract: In this work, we develop a novel method that bridges between material properties of proteins, particularly the modulus of elasticity, and the underlying molecular interactions. To this end, we employ both an all-atom normal mode… read more here.
Keywords: underlying molecular; young moduli; properties proteins; molecular interactions ... See more keywords
MicroRNAs in tear fluids predict underlying molecular changes associated with Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2023 at "Life Science Alliance"
DOI: 10.26508/lsa.202201757
Abstract: This study demonstrated the translational potential of deregulated tear fluid miRNAs associated with amyloid beta production and proinflammation in a transgenic AD mouse model. Extracellular circulating microRNAs (miRNAs) have been discussed as potential biomarkers for… read more here.
Keywords: disease; alzheimer disease; mirnas associated; expression levels ... See more keywords
Perioperative changes in inflammatory biomarkers and underlying molecular mechanisms in patients with trigeminal neuralgia undergoing surgical interventions
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2025.1633630
Abstract: Trigeminal neuralgia (TN) is a very painful neurological condition with unilateral and electric shock-like pain attacks. The accurate diagnosis of the disease is of extreme importance for the determination of subsequent therapeutic strategies and clinical… read more here.
Keywords: inflammatory biomarkers; surgical interventions; perioperative changes; underlying molecular ... See more keywords
Insecticidal activity and underlying molecular mechanisms of a phytochemical plumbagin against Spodoptera frugiperda
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2024.1427385
Abstract: Introduction Plumbagin is an important phytochemical and has been reported to exhibit potent larvicidal activity against several insect pests, However, the insecticidal mechanism of plumbagin against pests is still poorly understood. This study aimed to… read more here.
Keywords: underlying molecular; phytochemical plumbagin; molecular mechanisms; plumbagin ... See more keywords
Axonal Regeneration: Underlying Molecular Mechanisms and Potential Therapeutic Targets
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10123186
Abstract: Axons in the peripheral nervous system have the ability to repair themselves after damage, whereas axons in the central nervous system are unable to do so. A common and important characteristic of damage to the… read more here.
Keywords: regeneration; axonal regeneration; regeneration underlying; molecular mechanisms ... See more keywords
RNA-Seq Reveals the Underlying Molecular Mechanism of First Cleavage Time Affecting Porcine Embryo Development
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.3390/genes13071251
Abstract: The selection and evaluation of high-quality embryos are the key factors affecting in vitro embryo development and pregnancy outcome. The timing of first embryonic cleavage has been considered a positive indicator of the in vitro… read more here.
Keywords: cleavage; development; embryo development; underlying molecular ... See more keywords