Using CRISPR to understand how cancer mutations happen
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DOI: 10.1038/s42003-021-02313-9
Abstract: Somatic mutations in cancer genomes can be caused by many different mutational processes, each of which produce distinctive patterns termed “mutational signatures”. Although cancer researchers can now recognize a large number of mutational signatures, exactly… read more here.
Keywords: cancer mutations; mutations happen; crispr understand; understand cancer ... See more keywords
A genome-wide net to catch and understand cancer
Sign Up to like & getrecommendations! Published in 2018 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.aat8288
Abstract: Genome-scale forward genetic screens elucidate the genetic basis of therapeutic resistance, tumor evolution, and metastasis in diverse human cancers. Genome-scale forward genetic screens elucidate the genetic basis of therapeutic resistance, tumor evolution, and metastasis in… read more here.
Keywords: genome wide; medicine; catch understand; net catch ... See more keywords
Using microRNA Networks to Understand Cancer
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms19071871
Abstract: Human cancers are characterized by deregulated expression of multiple microRNAs (miRNAs), involved in essential pathways that confer the malignant cells their tumorigenic potential. Each miRNA can regulate hundreds of messenger RNAs (mRNAs), while various miRNAs… read more here.
Keywords: networks understand; mirna; microrna networks; using microrna ... See more keywords