Understanding and Circumventing the Requirement for Native Thioester Substrates for α-Oxoamine Synthase Reactions.
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DOI: 10.1021/acschembio.2c00365
Abstract: Many enzyme classes require thioester electrophiles such as acyl-carrier proteins and acyl-coenzyme A substrates. For in vitro applications, these substrates can render these chemical transformations impractical. To address this challenge, we have investigated the mechanism… read more here.
Keywords: oxoamine synthase; understanding circumventing; native thioester; circumventing requirement ... See more keywords