Understanding drug targets: no such thing as bad news.
Sign Up to like & getrecommendations! Published in 2018 at "Drug discovery today"
DOI: 10.1016/j.drudis.2018.05.028
Abstract: How can small-to-medium pharma and biotech companies enhance the chances of running a successful drug project and maximise the return on a limited number of assets? Having a full appreciation of the safety risks associated… read more here.
Keywords: drug targets; targets thing; thing bad; bad news ... See more keywords
A current understanding of drug-induced QT prolongation and its implications for anticancer therapy.
Sign Up to like & getrecommendations! Published in 2019 at "Cardiovascular research"
DOI: 10.1093/cvr/cvz013
Abstract: The QT interval, a global index of ventricular repolarization, varies among individuals and is influenced by diverse physiologic and pathophysiologic stimuli such as gender, age, heart rate, electrolyte concentrations, concomitant cardiac disease, and other diseases… read more here.
Keywords: induced prolongation; drug induced; drug; understanding drug ... See more keywords
Understanding Drug Sensitivity and Tackling Resistance in Cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer research"
DOI: 10.1158/0008-5472.can-21-3695
Abstract: Decades of research into the molecular mechanisms of cancer and the development of novel therapeutics have yielded a number of remarkable successes. However, our ability to broadly assign effective, rationally targeted therapies in a personalized… read more here.
Keywords: cancer; understanding drug; resistance; sensitivity tackling ... See more keywords