Understanding interspecies drug response variations between human and rodent P2X7 receptors
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DOI: 10.1038/s41467-025-65847-0
Abstract: Despite intensive development, P2X7 modulators have struggled in translation due to human genetic variability and species-dependent drug responses. Here, we identify PSFL1191, a portal-of-central-pocket (PCP)-site inhibitor selective for human and panda P2X7, but inactive against… read more here.
Keywords: p2x7; drug response; understanding interspecies; drug ... See more keywords