Understanding the Metabolism of Proteolysis Targeting Chimeras (PROTACs): The Next Step toward Pharmaceutical Applications
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DOI: 10.1021/acs.jmedchem.0c00793
Abstract: Hetero-bifunctional PROteolysis TArgeting Chimeras (PROTACs) represent a new emerging class of small molecules designed to induce polyubiquitylation and proteasomal-dependent degradation of a target protein. Despite the increasing number of publications about the synthesis, biological evaluation,… read more here.
Keywords: understanding metabolism; metabolism; targeting chimeras; proteolysis targeting ... See more keywords