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   Articles with "understanding molecular" as a keyword



Towards Understanding the Molecular Mechanisms of Immunogenic Cell Death

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recommendations! Published in 2022 at "ChemBioChem"

DOI: 10.1002/cbic.202200621

Abstract: The discovery of immunogenic cell death (ICD) by small molecules (e. g., chemotherapeutic drugs) intrigued medicinal chemists and led them to exploit anticancer agents with such a trait because ICD agents provoke anticancer immune responses in… read more here.

Keywords: cell death; understanding molecular; towards understanding; immunogenic cell ... See more keywords

Understanding the Molecular Origin of the Collective Movement in a Diarylethene‐based Photo‐Responsive Actuator

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recommendations! Published in 2021 at "Chemphyschem"

DOI: 10.1002/cphc.202100446

Abstract: Abstract Remotely controlling macroscopic movement is one of the key elements to realize intelligent materials for applications ranging from sensing to robotics. Over the last few years, a number of photomechanical materials based on diarylethene… read more here.

Keywords: movement; molecular origin; photo; origin collective ... See more keywords

Discriminating and understanding molecular crystal polymorphism

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recommendations! Published in 2022 at "Journal of Computational Chemistry"

DOI: 10.1002/jcc.27057

Abstract: Polymorph discrimination for a molecular crystal has long been a challenging task, which, nonetheless, is a major concern in the pharmaceutical industry. In this work, we have investigated polymorph discrimination on three different molecular crystals,… read more here.

Keywords: discriminating understanding; polymorphism; understanding molecular; crystal polymorphism ... See more keywords

Understanding the Molecular Mechanism of Cation Permeation in the Cardiac Ryanodine Receptor (RyR2) Channel using Computational Electrophysiology

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recommendations! Published in 2018 at "Biophysical Journal"

DOI: 10.1016/j.bpj.2017.11.665

Abstract: 582-Pos Board B352 Strained Collagen Resists Bacterial Collagenase Degradation Karanvir Saini, Manorama Tiwari, Jerome Irianto, Charlotte Pfeifer, Cory Alvey, Dennis E. Discher. Univ of Pennsylvania, Univ of Pennsylvania, Philadelphia, PA, USA. Background: Collagen, a triple-helical,… read more here.

Keywords: collagen; collagen fibrils; mechanical strain; strain ... See more keywords
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Understanding Molecular Drivers of Melanin Binding To Support Rational Design of Small Molecule Ophthalmic Drugs.

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recommendations! Published in 2018 at "Journal of medicinal chemistry"

DOI: 10.1021/acs.jmedchem.8b01281

Abstract: Binding of drugs to ocular melanin is a prominent biological phenomenon that affects the local pharmacokinetics and pharmacodynamics in the eye. In this work, we report on the development of in vitro and in silico… read more here.

Keywords: binding support; melanin; molecular drivers; melanin binding ... See more keywords

Cardiac conduction diseases: understanding the molecular mechanisms to uncover targets for future treatments

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recommendations! Published in 2024 at "Expert Opinion on Therapeutic Targets"

DOI: 10.1080/14728222.2024.2351501

Abstract: ABSTRACT Introduction The cardiac conduction system (CCS) is crucial for maintaining adequate cardiac frequency at rest and modulation during exercise. Furthermore, the atrioventricular node and His-Purkinje system are essential for maintaining atrioventricular and interventricular synchrony… read more here.

Keywords: conduction diseases; molecular mechanisms; diseases understanding; understanding molecular ... See more keywords

The coral microbiome: towards an understanding of the molecular mechanisms of coral–microbiota interactions

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recommendations! Published in 2023 at "FEMS Microbiology Reviews"

DOI: 10.1093/femsre/fuad005

Abstract: Abstract Corals live in a complex, multipartite symbiosis with diverse microbes across kingdoms, some of which are implicated in vital functions, such as those related to resilience against climate change. However, knowledge gaps and technical… read more here.

Keywords: coral microbiome; microbiome towards; molecular mechanisms; understanding molecular ... See more keywords

Understanding molecular mechanisms and predicting phenotypic effects of pathogenic tubulin mutations

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recommendations! Published in 2022 at "PLoS Computational Biology"

DOI: 10.1101/2022.06.16.496400

Abstract: Cells rely heavily on microtubules for several processes, including cell division and molecular trafficking. Mutations in the different tubulin-α and -β proteins that comprise microtubules have been associated with various diseases and are often dominant,… read more here.

Keywords: mechanisms predicting; molecular mechanisms; tubulin mutations; understanding molecular ... See more keywords
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Advances in understanding the molecular mechanisms of venous thrombosis

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recommendations! Published in 2019 at "British Journal of Haematology"

DOI: 10.1111/bjh.15869

Abstract: Venous thromboembolism (VTE) represents a leading cause of global mortality, however, the determinants that contribute to thrombus development remain incompletely understood. In this review, we discuss the role of inherited abnormalities of blood coagulation in… read more here.

Keywords: venous thrombosis; advances understanding; mechanisms venous; role ... See more keywords

Progress in Understanding the Molecular Mechanisms Underlying the Antitumour Effects of Ivermectin

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recommendations! Published in 2020 at "Drug Design, Development and Therapy"

DOI: 10.2147/dddt.s237393

Abstract: Abstract Ivermectin, a dihydro derivative of avermectin (AVM), was introduced into the veterinary, agricultural and aquaculture markets for animal health in 1981. Ivermectin was soon adopted in 1987 as a human medicine that was originally… read more here.

Keywords: understanding molecular; antitumour effects; cancer; progress understanding ... See more keywords

Understanding Molecular Mechanisms of the Brain Through Transcriptomics

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recommendations! Published in 2019 at "Frontiers in Physiology"

DOI: 10.3389/fphys.2019.00214

Abstract: The brain is the most complicated organ in the human body with more than ten thousand genes expressed in each region. The molecular activity of the brain is divergent in various brain regions, both spatially… read more here.

Keywords: mechanisms brain; brain transcriptomics; molecular mechanisms; brain ... See more keywords