Understanding the pathway and kinetics of aspartic acid isomerization in peptide mapping methods for monoclonal antibodies
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DOI: 10.1007/s00216-021-03176-z
Abstract: Isomerization of aspartic acid (Asp) in therapeutic proteins could lead to safety and efficacy concerns. Thus, accurate quantitation of various Asp isomerization along with kinetic understanding of the variant formations is needed to ensure optimal… read more here.
Keywords: aspartic acid; understanding pathway; isomerization; pathway kinetics ... See more keywords