Holistic similarity-based prediction of phosphorylation sites for understudied kinases
Sign Up to like & getrecommendations! Published in 2023 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbac624
Abstract: Phosphorylation is an essential mechanism for regulating protein activities. Determining kinase-specific phosphorylation sites by experiments involves time-consuming and expensive analyzes. Although several studies proposed computational methods to model kinase-specific phosphorylation sites, they typically required abundant… read more here.
Keywords: understudied kinases; experimentally verified; similarity; phosphorylation sites ... See more keywords
KinOrtho: a method for mapping human kinase orthologs across the tree of life and illuminating understudied kinases
Sign Up to like & getrecommendations! Published in 2021 at "BMC Bioinformatics"
DOI: 10.1186/s12859-021-04358-3
Abstract: Background Protein kinases are among the largest druggable family of signaling proteins, involved in various human diseases, including cancers and neurodegenerative disorders. Despite their clinical relevance, nearly 30% of the 545 human protein kinases remain… read more here.
Keywords: kinase orthologs; kinase; illuminating understudied; understudied kinases ... See more keywords