Recurrent mutations in topoisomerase IIα cause a previously undescribed mutator phenotype in human cancers
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DOI: 10.1073/pnas.2114024119
Abstract: Significance Topoisomerases are crucial for genome maintenance and are targets for several chemotherapeutic agents. While anticancer drugs targeting topoisomerases can lead to secondary malignancies, there have been no descriptions of genetic defects in topoisomerases having… read more here.
Keywords: undescribed mutator; cleavage; topoisomerase; previously undescribed ... See more keywords