Unearthing Hidden Chemical Potential from Discarded Actinobacterial Libraries.
Sign Up to like & getrecommendations! Published in 2019 at "Trends in biotechnology"
DOI: 10.1016/j.tibtech.2019.11.003
Abstract: The redundancy of natural product biosynthesis in microbes poses a practical challenge for discovering new antimicrobial compounds from bacteria. The recent application of clustered regularly interspaced short palindromic repeats (CRISPR) technology by Culp et al. to… read more here.
Keywords: unearthing hidden; chemical potential; actinobacterial libraries; discarded actinobacterial ... See more keywords
Mining and unearthing hidden biosynthetic potential
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-24133-5
Abstract: Genetically encoded small molecules (secondary metabolites) play eminent roles in ecological interactions, as pathogenicity factors and as drug leads. Yet, these chemical mediators often evade detection, and the discovery of novel entities is hampered by… read more here.
Keywords: unearthing hidden; mining unearthing; mining; biosynthetic potential ... See more keywords