Unexpected role of natural killer cell‐derived interferon‐γ as a driver of NETosis and DVT
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.14368
Abstract: Acute deep vein thrombosis (DVT) and its most severe clinical complication pulmonary embolism (PE), is an important contributor to global cardiovascular mortality [1, 2]. VTE can be caused by several factors, including inflammation [3]. It… read more here.
Keywords: killer cell; cell derived; natural killer; role natural ... See more keywords
Unexpected role of SIX1 variants in craniosynostosis: expanding the phenotype of SIX1-related disorders
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Medical Genetics"
DOI: 10.1136/jmedgenet-2020-107459
Abstract: Pathogenic heterozygous SIX1 variants (predominantly missense) occur in branchio-otic syndrome (BOS), but an association with craniosynostosis has not been reported.We investigated probands with craniosynostosis of unknown cause using whole exome/genome (n=628) or RNA (n=386) sequencing,… read more here.
Keywords: six1 variants; role six1; craniosynostosis; six1 ... See more keywords
Unexpected role of dendritic cells in pulmonary fibrosis
Sign Up to like & getrecommendations! Published in 2019 at "Thorax"
DOI: 10.1136/thoraxjnl-2019-213510
Abstract: Pulmonary fibrosis is one of the most devastating diseases in which scars are formed in the lungs in a progressive and non-reversible fashion resulting in breathlessness and respiratory failure. Some treatments may improve symptoms or… read more here.
Keywords: role dendritic; fibrosis; dendritic cells; pulmonary fibrosis ... See more keywords
Knockout of Anopheles stephensi immune gene LRIM1 by CRISPR-Cas9 reveals its unexpected role in reproduction and vector competence.
Sign Up to like & getrecommendations! Published in 2021 at "PLoS pathogens"
DOI: 10.1371/journal.ppat.1009770
Abstract: PfSPZ Vaccine against malaria is composed of Plasmodium falciparum (Pf) sporozoites (SPZ) manufactured using aseptically reared Anopheles stephensi mosquitoes. Immune response genes of Anopheles mosquitoes such as Leucin-Rich protein (LRIM1), inhibit Plasmodium SPZ development (sporogony)… read more here.
Keywords: vector competence; crispr cas9; lrim1; anopheles stephensi ... See more keywords
New unexpected role for Wolfram Syndrome protein WFS1: a novel therapeutic target for Alzheimer’s disease?
Sign Up to like & getrecommendations! Published in 2022 at "Neural Regeneration Research"
DOI: 10.4103/1673-5374.361540
Abstract: Selective vulnerability of excitatory neurons in Alzheimer’s disease (AD): AD is the most common form of dementia; however, the pathogenesis of AD is largely unknown. One of the characteristic features of AD is the formation… read more here.
Keywords: new unexpected; disease; alzheimer disease; role wolfram ... See more keywords