An unexpected synthesis of β-amino-α-mesyl-γ-sultams upon mesylation of hindered α-aminonitriles
Sign Up to like & getrecommendations! Published in 2020 at "Chemistry of Heterocyclic Compounds"
DOI: 10.1007/s10593-020-02671-y
Abstract: We report one-pot procedure for an unexpected synthesis of previously unknown 4-amino-5-methylsulfonyl-2,3-dihydroisothiazole 1,1-dioxides (also called β-amino-α-mesyl-γ-sultams). Thus, the reaction of mesyl chloride with hindered α-aminonitriles is accompanied by the formation of interim N -(1-cyanoalkyl)(methylsulfonyl)methanesulfonamides which,… read more here.
Keywords: amino mesyl; amino; hindered aminonitriles; unexpected synthesis ... See more keywords
Green, unexpected synthesis of bis-coumarin derivatives as potent anti-bacterial and anti-inflammatory agents.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.10.072
Abstract: A green and efficient protocol has been developed and a series of coumarin based pyrano[3,2-c]chromene derivatives (2) have been synthesized using multi-component reaction (MCR) approach. Unexpected 3-coumarinyl-3-pyrazolylpropanoic acids (3) and C4-C4 chromenes (5) have been… read more here.
Keywords: anti inflammatory; coumarin; green unexpected; unexpected synthesis ... See more keywords
Unexpected synthesis of novel 2-pyrone derivatives: crystal structures, Hirshfeld surface analysis and computational studies
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2020.1780943
Abstract: Abstract Here we report synthesis of three new compounds namely, 1-acetyl-1H-benzimidazolo-2(3H)-one (I), N-(5-acetyl-6-methyl-2-oxo-2H-pyran-4-yl)-N-(2-acetamidophenyl)acetamide (II) and N-(2-acetamidophenyl)-N-2-oxo-2H-pyran-4-yl)acetamide (III) have been synthesized and characterized by single crystal X-ray diffraction. Compounds I and II crystallize in the monoclinic… read more here.
Keywords: unexpected synthesis; synthesis novel; hirshfeld surface; surface analysis ... See more keywords
Unexpected synthesis and crystal structure of N-{2-[2-(2-acetylethenyl)phenoxy]ethyl}-N-ethenyl-4-methylbenzenesulfonamide
Sign Up to like & getrecommendations! Published in 2020 at "Acta Crystallographica Section E: Crystallographic Communications"
DOI: 10.1107/s2056989020015194
Abstract: The title N-tosylated secondary vinylamine was obtained by alkaline treatment of 1,5-bis(1-phenoxy)-3-azapentane at moderate heating. Theoretical predictions suggest that the title compound could inhibit gluconate 2-dehydrogenase (85% probability), as well as to act as a… read more here.
Keywords: phenoxy ethyl; crystal structure; unexpected synthesis; acetylethenyl phenoxy ... See more keywords
Tales of the Unexpected in Synthesis of Polyfunctional Heteroaromatics
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DOI: 10.2174/1570179414666171116152921
Abstract: Background: Our research group has a longstanding interest in the synthesis of novel functionalized heteroaromatic compounds, and the development of new methods for this purpose. During our ongoing ... read more here.
Keywords: tales unexpected; synthesis polyfunctional; unexpected synthesis; polyfunctional heteroaromatics ... See more keywords