IRE1α nucleotide sequence cleavage specificity in the unfolded protein response
Sign Up to like & getrecommendations! Published in 2017 at "FEBS Letters"
DOI: 10.1002/1873-3468.12546
Abstract: Inositol‐requiring enzyme 1 (IRE1) is a conserved sensor of the unfolded protein response that has protein kinase and endoribonuclease (RNase) enzymatic activities and thereby initiates HAC1/XBP1 splicing. Previous studies demonstrated that human IRE1α (hIRE1α) does… read more here.
Keywords: cleavage; unfolded protein; protein response; cleavage specificity ... See more keywords
Copper Increases the Sensitivity of Cholangiocarcinoma Cells to Tripterine by Inhibiting TMX2-Mediated Unfolded Protein Reaction Activation.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202300913
Abstract: Chemotherapy-induced adaptive resistance is a significant factor that contributes to low therapeutic efficacy in tumor cells. The unfolded protein response (UPR) is a key mechanism in the development of drug resistance and serves as a… read more here.
Keywords: unfolded protein; cholangiocarcinoma; tmx2; increases sensitivity ... See more keywords
Inhibiting the IRE1α Axis of the Unfolded Protein Response Enhances the Antitumor Effect of AZD1775 in TP53 Mutant Ovarian Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202105469
Abstract: Targeting the G2/M checkpoint mediator WEE1 has been explored as a novel treatment strategy in ovarian cancer, but mechanisms underlying its efficacy and resistance remains to be understood. Here, it is demonstrated that the WEE1… read more here.
Keywords: tp53 mutant; unfolded protein; ovarian cancer; protein response ... See more keywords
ONC201 induces the unfolded protein response (UPR) in high‐ and low‐grade ovarian carcinoma cell lines and leads to cell death regardless of platinum sensitivity
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Medicine"
DOI: 10.1002/cam4.3858
Abstract: Treatment of both platinum resistant high grade (HG) and low‐grade (LG) ovarian cancer (OVCA) poses significant challenges as neither respond well to conventional chemotherapy leading to morbidity and mortality. Identification of novel agents that can… read more here.
Keywords: platinum; unfolded protein; grade ovarian; low grade ... See more keywords
HIV‐1 Tat‐induced bystander apoptosis in Jurkat cells involves unfolded protein responses
Sign Up to like & getrecommendations! Published in 2018 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.3357
Abstract: The HIV transactivator protein (Tat) is a multifunctional protein that plays a critical role in viral replication and contributes to several pathological symptoms of HIV‐1 infection, which has the loss of CD4+ T lymphocytes as… read more here.
Keywords: jurkat; apoptosis jurkat; unfolded protein; jurkat cells ... See more keywords
Perfluorooctanoic acid activates the unfolded protein response in pancreatic acinar cells
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22561
Abstract: Perfluoroalkyl substances, such as perfluorooctanoic acid (PFOA), are widely used in consumer and industrial applications. Human epidemiologic and animal studies suggest that PFOA exposure elicits adverse effects on the pancreas; however, little is known about… read more here.
Keywords: perfluorooctanoic acid; pancreatic acinar; pfoa; unfolded protein ... See more keywords
Vitexin prevents Aβ proteotoxicity in transgenic Caenorhabditis elegans model of Alzheimer's disease by modulating unfolded protein response
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22632
Abstract: Alzheimer's disease (AD) accounts for an estimated 60% to 80% of all dementia cases. The present study is aimed at evaluating the neuroprotective efficacy of vitexin, an apigenin flavone glycoside using transgenic Caenorhabditis elegans strain… read more here.
Keywords: vitexin; unfolded protein; alzheimer disease; protein response ... See more keywords
MicroRNA‐382 silencing induces a mitonuclear protein imbalance and activates the mitochondrial unfolded protein response in muscle cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27401
Abstract: Proper mitochondrial function plays a central role in cellular metabolism. Various diseases as well as aging are associated with diminished mitochondrial function. Previously, we identified 19 miRNAs putatively involved in the regulation of mitochondrial metabolism… read more here.
Keywords: imbalance; unfolded protein; muscle; protein response ... See more keywords
The joint action of unfolded protein response, circZc3h4, and circRNA Scar in procymidone‐induced testicular injury in adolescent mice
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology"
DOI: 10.1002/tox.23622
Abstract: Procymidone (PCM) is a low toxicity fungicide, and an endocrine‐disrupting chemical (EDC) that particularly damages the reproductive system of male vertebrates. In present study, adolescent mice in control, low‐, medium‐, and high‐dose groups were orally… read more here.
Keywords: unfolded protein; response; adolescent mice; circrna scar ... See more keywords
The role and mechanism of unfolded protein response signaling pathway in methylmercury‐induced apoptosis of mouse spermatocytes germ cell‐2 cells
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology"
DOI: 10.1002/tox.23684
Abstract: The study aimed to explore the role and mechanism of unfolded protein response (UPR) in methylmercury (MeHg)‐induced Mouse Spermatocytes (GC‐2spd[ts]) apoptosis. Methods such as MTT, flow cytometry, and Western Blot were used to evaluate the… read more here.
Keywords: cell; unfolded protein; apoptosis; mechanism unfolded ... See more keywords
Detection of Unfolded Protein Response by Polymerase Chain Reaction.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1162-3_2
Abstract: The unfolded protein response is a cellular adaptive mechanism localized in the endoplasmic reticulum. It involves three phases: the detection of increased presence of unfolded proteins as a result of cellular stressors; the execution of… read more here.
Keywords: unfolded protein; protein response; response polymerase; detection unfolded ... See more keywords