T cells engrafted with a UniCAR 28/z outperform UniCAR BB/z-transduced T cells in the face of regulatory T cell-mediated immunosuppression
Sign Up to like & getrecommendations! Published in 2019 at "Oncoimmunology"
DOI: 10.1080/2162402x.2019.1621676
Abstract: ABSTRACT Adoptive transfer of chimeric antigen receptor (CAR)-equipped T cells have demonstrated astonishing clinical efficacy in hematological malignancies recently culminating in the approval of two CAR T cell products. Despite this tremendous success, CAR T… read more here.
Keywords: unicar transduced; mediated immunosuppression; cell; unicar ... See more keywords
P06.11 Immunotargeting of CD98hc for elimination of radioresistant head and neck squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2020 at "Journal for ImmunoTherapy of Cancer"
DOI: 10.1136/jitc-2020-itoc7.90
Abstract: Background Most patients with head and neck squamous cell carcinomas (HNSCC) are diagnosed during a locally advanced stage and may show therapy resistance. Retrospectively, we showed that low CD98hc mRNA and protein levels are significantly… read more here.
Keywords: none; neck squamous; cell; unicar ... See more keywords
Development of Target Modules for Early and Late Stage Cancer Treatment Using Switchable Unicar T Cell Therapy
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DOI: 10.1182/blood-2019-128249
Abstract: The clinical efficacy of CAR T cell therapies has been widely recognized, particularly in the treatment of hematologic malignancies. Nevertheless, CAR T cells also have the capability to elicit undesired effects such as on-target/off-tumor recognition… read more here.
Keywords: unicar cells; treatment; unicar; cell ... See more keywords
Validation of CD98hc as a Therapeutic Target for a Combination of Radiation and Immunotherapies in Head and Neck Squamous Cell Carcinoma
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DOI: 10.3390/cancers14071677
Abstract: Simple Summary The outcome of patients with locally advanced head and neck squamous cell carcinoma (HNSCC) has not changed for the past decade despite advances in treatment strategies. SLC3A2, which encodes CD98hc, was identified as… read more here.
Keywords: hnscc; treatment; cd98hc; combination ... See more keywords
Targeting CD10 on B-Cell Leukemia Using the Universal CAR T-Cell Platform (UniCAR)
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23094920
Abstract: Chimeric antigen receptor (CAR)-expressing T-cells are without a doubt a breakthrough therapy for hematological malignancies. Despite their success, clinical experience has revealed several challenges, which include relapse after targeting single antigens such as CD19 in… read more here.
Keywords: cell; platform; cd10; car ... See more keywords