A unified molecular mechanism for the regulation of acetyl-CoA carboxylase by phosphorylation
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DOI: 10.1038/celldisc.2016.55
Abstract: Acetyl-CoA carboxylases (ACCs) are crucial metabolic enzymes and attractive targets for drug discovery. Eukaryotic acetyl-CoA carboxylases are 250 kDa single-chain, multi-domain enzymes and function as dimers and higher oligomers. Their catalytic activity is tightly regulated by… read more here.
Keywords: unified molecular; carboxylase; molecular mechanism; acetyl coa ... See more keywords
The Common Concept of Anticooperativity Among Molecules Is Fundamentally Flawed, Based on Novel and Unified Molecular-Wide and Electron Density (MOWeD) Concept of Chemical Bonding
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DOI: 10.3390/molecules30091944
Abstract: A non-linear (non-additive) increase in stability of hexamers follows an increase in the total number of (i) aad (a double proton acceptor) plus add (a double proton donor) waters commonly linked with anticooperativity and (ii)… read more here.
Keywords: electron density; unified molecular; density mowed; wide electron ... See more keywords